NDLI: Studying the effect of iris mechanics on the pupillary light reflex using brimonidine-induced anisocoria.

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Studying the effect of iris mechanics on the pupillary light reflex using brimonidine-induced anisocoria.

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Studying the effect of iris mechanics on the pupillary light reflex using brimonidine-induced anisocoria.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kardon, Randy H. Chen, Yanjun
Description	Country affiliation: United States Author Affiliation: Chen Y ( Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA. ychen@ophth.wisc.edu)
Abstract	PURPOSE: To study and correct for the limiting effect of iris mechanics on the amplitude of light-evoked pupil contractions in order to derive a more clinically accurate assessment of afferent input to the visual system. METHODS: Transient pupil responses were recorded to a series of 1-second red Ganzfeld light stimuli with a stepwise increase in stimulus intensity using a binocular infrared computerized pupillometer. One eye of eight healthy subjects was treated with 0.2% brimonidine tartrate ophthalmic solution to induce pupil size reduction. The amount of pupil contraction as a function of stimulus intensity was compared between the brimonidine-treated, miotic eye and the untreated eye. RESULTS: BRIMONIDINE TREATMENT PRODUCED SIGNIFICANT REDUCTION IN PUPIL SIZE IN HEALTHY SUBJECTS (MEAN REDUCTION IN PUPIL SIZE: 1.78 ± 0.35 mm, P < 0.05). For increasing light intensity, the treated pupil started to show reduced pupil contractions compared with the contralateral untreated pupil when the peak of pupil contraction reached an average pupil size of 3.25 ± 0.61 mm (range, 2.38-4.44 mm). When measured by percent pupil contraction (contraction amplitude/baseline pupil diameter), the pupil response as a function of stimulus intensity in the treated, miotic eye did not differ from that in the untreated eye. CONCLUSIONS: Iris mechanics limits the amount of pupil contraction and can act to reduce the assessed neuronal integration of the pupil light reflex. Pupil response assessed by using percent contraction amplitude is least affected by mechanical effects and provides a more accurate approximation of afferent input.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.12-10916
Journal	Investigative Opthalmology & Visual Science
Issue Number	4
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-04-26
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Quinoxalines Pharmacology Reflex, Pupillary Drug Effects Sympatholytics Anisocoria Chemically Induced Physiopathology Brimonidine Tartrate Physiology Ophthalmic Solutions Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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