NDLI: Comparison of drusen area detected by spectral domain optical coherence tomography and color fundus imaging.

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Comparison of drusen area detected by spectral domain optical coherence tomography and color fundus imaging.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rosenfeld, Philip J. Gregori, Giovanni Feuer, William J. Li, Ying Yehoshua, Zohar Sadda, SriniVas R. Penha, Fernando M. Konduru, Ranjith K. Nittala, Muneeswar G. Gupta, Pooja Goldhardt, Raquel
Description	Country affiliation: United States Author Affiliation: Yehoshua Z ( Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.)
Abstract	PURPOSE: To compare the measurements of drusen area from manual segmentation of color fundus photographs with those generated by an automated algorithm designed to detect elevations of the retinal pigment epithelium (RPE) on spectral domain optical coherence tomography (SD-OCT) images. METHODS: Fifty eyes with drusen secondary to nonexudative age-related macular degeneration were enrolled. All eyes were imaged with a high-definition OCT instrument using a 200 × 200 A-scan raster pattern covering a 6 mm × 6 mm area centered on the fovea. Digital color fundus images were taken on the same day. Drusen were traced manually on the fundus photos by graders at the Doheny Image Reading Center, whereas quantitative OCT measurements of drusen were obtained by using a fully automated algorithm. The color fundus images were registered to the OCT data set and measurements within corresponding 3- and 5-mm circles centered at the fovea were compared. RESULTS: The mean areas (± SD [range]) for the 3-mm circles were SD-OCT = 1.57 (± 1.08 [0.03-4.44]); 3-mm color fundus = 1.92 (± 1.08 [0.20-3.95]); 5-mm SD-OCT = 2.12 (± 1.55 [0.03-5.40]); and 5-mm color fundus = 3.38 (± 1.90 [0.39-7.49]). The mean differences between color images and the SD-OCT (color - SD-OCT) were 0.36 (± 0.93) (P = 0.008) for the 3-mm circle and 1.26 (± 1.38) (P < 0.001) for the 5-mm circle measurements. Intraclass correlation coefficients of agreements for 3- and 5-mm measurements were 0.599 and 0.540, respectively. CONCLUSIONS: There was only fair agreement between drusen area measurements obtained from SD-OCT images and color fundus photos. Drusen area measurements on color fundus images were larger than those with SD-OCT scans. This difference can be attributed to the fact that the OCT algorithm defines drusen in terms of RPE deformations above a certain threshold, and will not include small, flat drusen and subretinal drusenoid deposits. The two approaches provide complementary information about drusen.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.12-11569
Journal	Investigative Opthalmology & Visual Science
Issue Number	4
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-04-03
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Diagnostic Techniques, Ophthalmological Retinal Drusen Diagnosis Tomography, Optical Coherence Fluorescein Angiography Geographic Atrophy Prospective Studies Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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