NDLI: Berberine suppresses Th17 and dendritic cell responses.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2013 Volume: 54 Issue: 14

Year: 2013 Volume: 54 Issue: 13

Year: 2013 Volume: 54 Issue: 12

Year: 2013 Volume: 54 Issue: 11

Year: 2013 Volume: 54 Issue: 10

Year: 2013 Volume: 54 Issue: 9

Year: 2013 Volume: 54 Issue: 8

Year: 2013 Volume: 54 Issue: 7

Year: 2013 Volume: 54 Issue: 6

Year: 2013 Volume: 54 Issue: 5

Year: 2013 Volume: 54 Issue: 4

Development and efficacy of a drug-releasing soft contact lens.

The ROCK inhibitor eye drop accelerates corneal endothelium wound healing.

Macular pigment optical density in young adults of South Asian origin.

Inhibition of defocus-induced myopia in chickens.

Hypothermia prevents gliosis and angiogenesis development in an experimental model of ischemic proliferative retinopathy.

Tomographic features of macula after successful macular hole surgery.

Orbital volume augmentation after injection of human orbital adipose-derived stem cells in rabbits.

Comparison of drusen area detected by spectral domain optical coherence tomography and color fundus imaging.

Effects of keratin and lung surfactant proteins on the surface activity of meibomian lipids.

Lacritin-Induced Secretion of Tear Proteins From Cultured Monkey Lacrimal Acinar Cells

Protection of human corneal epithelial cells from TNF- -induced disruption of barrier function by rebamipide.

Interaction between conjunctival epithelial cells and mast cells induces CCL2 expression and piecemeal degranulation in mast cells.

Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis.

An ultra-high-speed Scheimpflug camera for evaluation of corneal deformation response and its impact on IOP measurement.

Contribution of Different Anatomical and Physiologic Factors to Iris Contour and Anterior Chamber Angle Changes During Pupil Dilation: Theoretical Analysis

Evaluation of corneal displacement using high-speed photography at the early and late phases of noncontact tonometry.

Berberine suppresses Th17 and dendritic cell responses.

Pupillometer-based objective chromatic perimetry in normal eyes and patients with retinal photoreceptor dystrophies.

Retinal and choroidal thickness in myopic anisometropia.

The impact of flash intensity on retinal vessel oxygen saturation measurements using dual wavelength oximetry.

Effect of growth factors on the proliferation and gene expression of human meibomian gland epithelial cells.

A genome-wide association study of central corneal thickness in Latinos.

Eyes in various species can shorten to compensate for myopic defocus.

Innate immune network in the retina activated by optic nerve crush.

Development, Composition, and Structural Arrangements of the Ciliary Zonule of the Mouse

Reproducibility of thickness measurements of macular inner retinal layers using SD-OCT with or without correction of ocular rotation.

In vivo chromatic aberration in eyes implanted with intraocular lenses.

Clinical, radiologic, and genetic features in blepharophimosis, ptosis, and epicanthus inversus syndrome in the Indian population.

Studying the effect of iris mechanics on the pupillary light reflex using brimonidine-induced anisocoria.

Prevalence of refractive errors in a multiethnic Asian population: the Singapore epidemiology of eye disease study.

Diverse mediators modulate the chloride ion fluxes that drive lacrimal fluid production.

Sensitivity and specificity of short-duration transient visual evoked potentials (SD-tVEP) in discriminating normal from glaucomatous eyes.

Pigment epithelium-derived factor is retinal ganglion cell neuroprotective and axogenic after optic nerve crush injury.

Genetic association of COL5A1 variants in keratoconus patients suggests a complex connection between corneal thinning and keratoconus.

Regulation of SPARC by transforming growth factor ß2 in human trabecular meshwork.

Structural and rheological properties of meibomian lipid.

Mobility experiments with microrobots for minimally invasive intraocular surgery.

Assessment of the impact of keratoconus on vision-related quality of life.

Investigating the relationship between foveal morphology and refractive error in a population with infantile nystagmus syndrome.

Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells.

Ocular inflammation and corneal permeability alteration by benzalkonium chloride in rats: a protective effect of a myosin light chain kinase inhibitor.

Blood flow of ophthalmic artery in healthy individuals determined by phase-contrast magnetic resonance imaging.

Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons.

Optimization of subconjunctival biodegradable microfilms for sustained drug delivery to the anterior segment in a small animal model.

Biomechanical properties and correlation with collagen solubility profile in the posterior sclera of canine eyes with an ADAMTS10 mutation.

All-trans-retinal sensitizes human RPE cells to alternative complement pathway-induced cell death.

Multifocal ERG recordings under visual control of the stimulated fundus in mice.

Antiapoptotic properties of -crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells.

Retrobulbar structure visualization with enhanced depth imaging optical coherence tomography.

Quantitative analysis of tear film fluorescence and discomfort during tear film instability and thinning.

Relationship between the second reflective band on optical coherence tomography and multifocal electroretinography in age-related macular degeneration.

Reflectance speckle of retinal nerve fiber layer reveals axonal activity.

Treatment of acute posterior uveitis in a porcine model by injection of triamcinolone acetonide into the suprachoroidal space using microneedles.

Spectrophotometric retinal oximetry in pigs.

Repeatability and reproducibility of choroidal vessel layer measurements in diabetic retinopathy using enhanced depth optical coherence tomography.

Associations of iris structural measurements in a Chinese population: the Singapore Chinese Eye Study.

Comparative analysis of repeatability of manual and automated choroidal thickness measurements in nonneovascular age-related macular degeneration.

Automated analysis of binocular alignment using an infrared camera and selective wavelength filter.

Pseudomonas aeruginosa small protease (PASP), a keratitis virulence factor.

Optimizing Chinese character displays improves recognition and reading performance of simulated irregular phosphene maps.

Treatment of geographic atrophy with subconjunctival sirolimus: results of a phase I/II clinical trial.

Quantitative fundus autofluorescence in mice: correlation with HPLC quantitation of RPE lipofuscin and measurement of retina outer nuclear layer thickness.

FIH-1/c-kit signaling: a novel contributor to corneal epithelial glycogen metabolism.

Comparative phospholipid profiles of control and glaucomatous human trabecular meshwork.

Impaired speed perception but intact luminance contrast perception in people with one eye.

Negative lens-induced myopia in infant monkeys: effects of high ambient lighting.

A genetic variant in the SKIV2L gene is significantly associated with age-related macular degeneration in a Han Chinese population.

DNA-PK phosphorylation of IGFBP-3 is required to prevent apoptosis in retinal endothelial cells cultured in high glucose.

Racial differences in lens opacity incidence and progression: the Salisbury Eye Evaluation (SEE) study.

Circulating mononuclear progenitor cells: differential roles for subpopulations in repair of retinal vascular injury.

Measurement of retinal blood flow rate in diabetic rats: disparity between techniques due to redistribution of flow.

Structural changes in the retinal microvasculature and renal function.

Automatic drusen quantification and risk assessment of age-related macular degeneration on color fundus images.

Effect of anterior chamber cannulation and acute IOP elevation on retinal macrophages in the adult mouse.

Correlation between the ganglion cell-inner plexiform layer thickness measured with cirrus HD-OCT and macular visual field sensitivity measured with microperimetry.

Systemic prostaglandin E1 to treat acute central retinal artery occlusion.

The effect of amniotic membrane de-epithelialization method on its biological properties and ability to promote limbal epithelial cell culture.

Mini-Chaperones for Early AMD.

Spotlight summary: quantitative fundus autofluorescence and A2E increase with aging in wild-type and 'Stargardt' mice.

Is impaired emmetropization related to foveal hypoplasia or is it specific to albinism?

Influence of the eye-tracking-based follow-up function in retinal nerve fiber layer thickness using fourier-domain optical coherence tomography.

Year: 2013 Volume: 54 Issue: 3

Year: 2013 Volume: 54 Issue: 2

Year: 2013 Volume: 54 Issue: 1

Year: 2012 Volume: 53

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Berberine suppresses Th17 and dendritic cell responses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Qi, Jian Yang, Peizeng Zhou, Yan Yu, Hongsong Du, Liping Yang, Yan Wang, Qian Kijlstra, Aize
Description	Author Affiliation: Yang Y ( First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China.)
Abstract	PURPOSE: Berberine (BBR) has been shown to exert immunosuppressive and anti-inflammatory effects in several autoimmune diseases. This study was designed to investigate the possible effect of BBR on Th17 and dendritic cell (DC) responses. METHODS: Twelve patients with active VKH disease and 20 healthy individuals were enrolled in this study. CD4(+) T cells and CD14(+) monocytes were isolated from peripheral blood mononuclear cells using magnetic-activated cell sorting. Monocyte-derived DCs were generated by culturing monocytes with GM-CSF and IL-4. Proinflammatory cytokines secreted by CD4(+) T cells and LPS induced DCs when exposed to BBR or only vehicle were detected by ELISA. The frequency of IL-17-producing CD4(+) T cells and the surface markers of BBR-treated DCs were measured by flow cytometry. RESULTS: Activation of CD4(+) T cells using anti-CD3 and anti-CD28 showed a higher Th17 response in active VKH patients. BBR showed a direct suppression of the Th17 response both in active VKH patients and healthy donors. It also suppressed the Th17 response indirectly by influencing DC maturation. On the one hand, BBR downregulated the expression of costimulatory molecules (CD40, CD80, and CD86) and, on the other hand, it inhibited IL-6, IL-1ß, and IL-23 secretion by DCs. CONCLUSIONS: These findings suggest that the inhibitory effect of BBR on the Th17 response was mediated by a direct action on T cells as well as an indirect effect via DCs. This study provides new evidence that the natural compound BBR is of great value in the search for novel therapeutic agents in the treatment of T-cell-mediated autoimmune diseases.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	4
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-04-05
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Berberine Pharmacology Dendritic Cells Drug Effects Immunosuppressive Agents Th17 Cells Antigens, Cd40 Metabolism Antigens, Cd80 Antigens, Cd86 Cd4-positive T-lymphocytes Cell Survival Coculture Techniques Cytokines Enzyme-linked Immunosorbent Assay Flow Cytometry Granulocyte-macrophage Colony-stimulating Factor Lipopolysaccharides Monocytes Uveomeningoencephalitic Syndrome Immunology Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in