NDLI: Optimization of ceragenins for prevention of bacterial colonization of hydrogel contact lenses.

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Optimization of ceragenins for prevention of bacterial colonization of hydrogel contact lenses.

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Optimization of ceragenins for prevention of bacterial colonization of hydrogel contact lenses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jennings, Jacob D. Savage, Paul B. Pollard, Jacob E. Gu, Xiaobo Snarr, Jason Chaudhary, Vinod
Description	Author Affiliation: Gu X ( Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah.)
Abstract	PURPOSE: We provided contact lens hydrogels with an antibacterial innate immune function using nonpeptide mimics of endogenous antimicrobial peptides. METHODS: Antimicrobial peptide mimics, ceragenins, were prepared for either covalent attachment to hydrogels or for controlled elution from lenses. The lipophilicity of the ceragenins was varied incrementally to provide differing levels of association with hydrophobic domains in lenses. Ceragenin-containing lenses were challenged repeatedly with Staphylococcus aureus or Pseudomonas aeruginosa in nutrient media. Bacterial growth and biofilm formation on lenses were quantified. RESULTS: A ceragenin covalently fixed in lenses effectively inhibited S. aureus biofilm formation on lenses in 10% tryptic soy broth (approximately 3-log reduction), but did not reduce biofilm formation in 100% tryptic soy broth. Ceragenins designed to elute from lenses were incorporated at 1% relative to the dry weight of the lenses. The ceragenin with the optimal lipid content, CSA-138, prevented bacterial colonization of lenses for 15 days with P. aeruginosa and for 30 days with S. aureus (daily exchange of growth media and reinoculation with 106 CFU). Measurement of CSA-138 elution showed that concentrations of the ceragenin never exceeded 5 µg/mL in a 24-hour period and that after 4 days of elution, concentrations dropped to <0.5 µg/mL, while maintaining antibacterial activity. CONCLUSIONS: Ceragenin CSA-138 appears well suited for providing an innate immune-like function to abiotic hydrogel contact lenses for extended periods of time. Elution of even low concentrations of CSA-138 (<0.5 µg) is sufficient to eliminate inocula of 106 CFU of S. aureus and P. aeruginosa.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-09-17
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Anti-infective Agents Pharmacology Contact Lenses, Hydrophilic Microbiology Eye Infections, Bacterial Prevention & Control Hydrogel Chemistry Steroids Biofilms Drug Effects Growth & Development Hydrophobic And Hydrophilic Interactions Microbial Sensitivity Tests Pseudomonas Infections Pseudomonas Aeruginosa Staphylococcal Infections Staphylococcus Aureus Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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