NDLI: Aqueous Humor Biomarkers of Müller Cell Activation in Diabetic Eyes.

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Aqueous Humor Biomarkers of Müller Cell Activation in Diabetic Eyes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vujosevic, Stela Midena, Edoardo Micera, Alessandra Esposito, Graziana Bini, Silvia Berton, Marianna
Description	Country affiliation: Italy Author Affiliation: Vujosevic S ( Department of Ophthalmology University of Padova, Padova, Italy.); Micera A ( Fondazione G. B. Bietti, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, Italy.); Bini S ( Department of Ophthalmology University of Padova, Padova, Italy.); Berton M ( Department of Ophthalmology University of Padova, Padova, Italy.); Esposito G ( Fondazione G. B. Bietti, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, Italy.); Midena E ( Department of Ophthalmology University of Padova, Padova, Italy 2Fondazione G. B. Bietti, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, Italy.)
Abstract	PURPOSE: To identify early biomarkers of retinal Müller cell activation in diabetic eyes with or without clinically detectable signs of diabetic retinopathy (DR). METHODS: This study was a cross-sectional comparative case series. The aqueous humor (AH) of 34 eyes was collected in 12 healthy controls, 11 diabetic patients without DR, and 11 diabetic patients with nonproliferative DR. Full ophthalmic examination and spectral-domain optical coherence tomography were performed in all eyes. Glial fibrillary acidic protein (GFAP), aquaporin 1 (AQP1), and aquaporin 4 (AQP4) were quantified in AH samples as biomarkers of Müller cell activity by ELISA. Statistical analysis was performed with ANOVA followed by Tukey-Kramer post hoc test. RESULTS: There was no significant difference in the age among the three groups. Mean concentration of GFAP, AQP1, and AQP4 significantly increased in diabetic eyes versus controls (P < 0.05, for each comparison). Glial fibrillary acidic protein and AQP1 showed an approximate 2-fold increase, whereas AQP4 showed an approximate 25-fold increase in diabetics with DR versus controls. In diabetics without DR, AQP4 showed an approximate 6-fold increase versus controls. CONCLUSIONS: Glial fibrillary acidic protein, AQP1, and AQP4-biomarkers of Müller cell activity-are significantly increased in human eyes with diabetes, confirming that Müller cells are precociously affected by diabetes mellitus.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aquaporin 1 Metabolism Aquaporin 4 Aqueous Humor Diabetic Retinopathy Ependymoglial Cells Glial Fibrillary Acidic Protein Analysis Of Variance Biological Markers Case-control Studies Cross-sectional Studies Retina Tomography, Optical Coherence Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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