NDLI: The Role of LOX-1 in Innate Immunity to Aspergillus fumigatus in Corneal Epithelial Cells.

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The Role of LOX-1 in Innate Immunity to Aspergillus fumigatus in Corneal Epithelial Cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhao, Guiqiu Liu, Ying Li, Cui Che, Chengye Jiang, Nan Lin, Jing Li, Na Hu, Liting
Abstract	PURPOSE: To determine the role of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) in corneal epithelial cells exposed to fungus. METHODS: Thirteen corneas with fungal keratitis composed the experimental group. Ten healthy donor corneas were the control group. Corneal epithelium was scraped and LOX-1 mRNA tested. Immunostaining was used to detect LOX-1 protein. Human corneal epithelial cells (HCECs) were treated with 75% ethanol-killed Aspergillus fumigatus. LOX-1 was detected, and CXCL1, TNF- , IL-6, and dectin-1 levels were detected with or without neutralization of LOX-1. Rat fungal keratitis was established and LOX-1 was detected by PCR, immunostaining, and Western blot. Phosphorylated-p38MAPK (p-p38MAPK) protein; CXCL1, TNF- , and IL-6 mRNA levels; and myeloperoxidase (MPO) were tested before and after LOX-1 neutralization. RESULTS: LOX-1 was expressed in corneal epithelium. In vitro cellular experiment showed that LOX-1 was detected in normal HCECs, and LOX-1 mRNA increased after stimulation of A. fumigatus and peaked at 8 hours; LOX-1 protein expression increased after stimulation at 24 and 48 hours. Neutralization of LOX-1 decreased expression of CXCL1, TNF- , but did not change IL-6 or dectin-1 expression. Aspergillus fumigatus keratitis developed in rats activated p38MAPK and elevated the expression of CXCL1, TNF- , and IL-6 through LOX-1. LOX-1 neutralization reduced MPO levels. CONCLUSIONS: LOX-1 expressed in normal corneal epithelium and HCECs and A. fumigatus elevated the expression of CXCL1 and TNF- through LOX-1. Rat A. fumigatus keratitis activated p38MAPK and elevated the expression of CXCL1, TNF- , and IL-6 through LOX-1.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aspergillus Fumigatus Physiology Epithelium, Corneal Microbiology Eye Infections, Fungal Immunity, Innate Keratitis Scavenger Receptors, Class E Metabolism Animals Antibodies, Neutralizing Pharmacology Case-control Studies Disease Models, Animal Epithelial Cells Immunology Rna, Messenger Rats, Wistar Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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