NDLI: A Single Intravitreal Injection of Ranibizumab Provides No Neuroprotection in a Nonhuman Primate Model of Moderate-to-Severe Nonarteritic Anterior Ischemic Optic Neuropathy.

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A Single Intravitreal Injection of Ranibizumab Provides No Neuroprotection in a Nonhuman Primate Model of Moderate-to-Severe Nonarteritic Anterior Ischemic Optic Neuropathy.

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A Single Intravitreal Injection of Ranibizumab Provides No Neuroprotection in a Nonhuman Primate Model of Moderate-to-Severe Nonarteritic Anterior Ischemic Optic Neuropathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Miller, Neil R. Johnson, Mary A. Nolan, Theresa Guo, Yan Bernstein, Steven L.
Description	Country affiliation: United States Author Affiliation: Miller NR ( The Wilmer Eye Institute the Johns Hopkins Medical Institutions, Baltimore, Maryland, United States 2Department of Ophthalmology and Visual Sciences, the University of Maryland School of Medicine, Baltimore, Maryland, United States.); Johnson MA ( Department of Ophthalmology and Visual Sciences, the University of Maryland School of Medicine, Baltimore, Maryland, United States.); Nolan T ( Department of Veterinary Resources, the University of Maryland School of Medicine, Baltimore, Maryland, United States.); Guo Y ( Department of Ophthalmology and Visual Sciences, the University of Maryland School of Medicine, Baltimore, Maryland, United States.); Bernstein SL ( Department of Ophthalmology and Visual Sciences, the University of Maryland School of Medicine, Baltimore, Maryland, United States.)
Abstract	PURPOSE: Ranibizumab, a vascular endothelial growth factor-antagonist, is said to be neuroprotective when injected intravitreally in patients with nonarteritic anterior ischemic optic neuropathy (NAION). We evaluated the efficacy of a single intravitreal (IVT) injection of ranibizumab in a nonhuman primate model of NAION (pNAION). METHODS: We induced pNAION in one eye of four adult male rhesus monkeys using a laser-activated rose Bengal induction method. We then immediately injected the eye with either ranibizumab or normal saline (NS) intravitreally. We performed a clinical assessment, optical coherence tomography, electrophysiological testing, fundus photography, and fluorescein angiography in three of the animals (one animal developed significant retinal hemorrhages and, therefore, could not be analyzed completely) prior to induction, 1 day and 1, 2, and 4 weeks thereafter. Following the 4-week analysis of the first eye, we induced pNAION in the contralateral eye and then injected either ranibizumab or NS, whichever substance had not been injected in the first eye. We euthanized all animals 5 to 12 weeks after the final assessment of the second eye and performed both immunohistochemical and light and electron microscopic analyses of the retina and optic nerves of both eyes. RESULTS: A single IVT dose of ranibizumab administered immediately after induction of pNAION resulted in no significant reduction of clinical, electrophysiological, or histologic damage compared with vehicle-injected eyes. CONCLUSIONS: A single IVT dose of ranibizumab is not neuroprotective when administered immediately after induction of pNAION.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.15-18015
Journal	Investigative Opthalmology & Visual Science
Issue Number	13
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Angiogenesis Inhibitors Pharmacology Evoked Potentials, Visual Drug Effects Optic Nerve Pathology Optic Neuropathy, Ischemic Ranibizumab Retina Administration & Dosage Animals Delayed-action Preparations Disease Models, Animal Electrophysiological Phenomena Fluorescein Angiography Intravitreal Injections Macaca Mulatta Neovascularization, Pathologic Retinal Ganglion Cells Rose Bengal Tomography, Optical Coherence Research Support, N.i.h., Extramural Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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