NDLI: Determination of in vivo estrogenic potential of Di-isobutyl phthalate (DIBP) and Di-isononyl phthalate (DINP) in rats.

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Determination of in vivo estrogenic potential of Di-isobutyl phthalate (DIBP) and Di-isononyl phthalate (DINP) in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sedha, Sapna Ahmad, R. Gautam, A. K. Verma, Y. Kumar, Sunil
Description	Country affiliation: India Author Affiliation: Sedha S ( Division of Reproductive and Cytotoxicology, National Institute of Occupational Health (ICMR), Meghaninagar, Ahmedabad, 380016, India.); Gautam AK ( Division of Reproductive and Cytotoxicology, National Institute of Occupational Health (ICMR), Meghaninagar, Ahmedabad, 380016, India.); Verma Y ( Division of Reproductive and Cytotoxicology, National Institute of Occupational Health (ICMR), Meghaninagar, Ahmedabad, 380016, India.); Ahmad R ( Division of Reproductive and Cytotoxicology, National Institute of Occupational Health (ICMR), Meghaninagar, Ahmedabad, 380016, India.); Kumar S ( Division of Reproductive and Cytotoxicology, National Institute of Occupational Health (ICMR), Meghaninagar, Ahmedabad, 380016, India. sunilnioh@yahoo.com.)
Abstract	Estrogenic potential of Di-isobutyl phthalate (DIBP) and Di-isononyl phthalate (DINP) was studied using two different test systems. Two different doses of DIBP (250 and 1250 mg/kg) and DINP (276 and 1380 mg/kg) were administered to immature female rats (20 days old) orally once daily for 3 and 20 days in uterotrophic and pubertal assay, respectively. The animals were sacrificed on day 4 and day 41 in case of 3-day uterotrophic and 20-day pubertal assay, respectively. The results indicated that non-significant alterations in uterine and ovarian wet weight were observed in both the DIBP- and DINP-treated groups while the uterus weight increased significantly (i.e., 4-6 times) in the Diethylstilbesterol (DES)-treated group in both the assays. In the present study, precocious vaginal opening occurred at 26 days of age in the DES-treated group with a mean body weight of 30.39 ± 1.08 g. However, no precocious vaginal opening was found in any of the DIBP- and DINP-treated groups. The results indicated that both the phthalate compounds were unable to induce elevation in the uterine weight in both the assays and unable to cause vaginal opening indicating non-estrogenic potential of both the phthalate compounds, i.e., DIBP and DINP in vivo.
ISSN	09441344
Issue Number	22
Volume Number	22
e-ISSN	16147499
Journal	Environmental Science and Pollution Research
Language	English
Publisher	Springer
Publisher Date	2015-11-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dibutyl Phthalate Analogs & Derivatives Estrogens Toxicity Phthalic Acids Animals Biological Assay Diethylstilbestrol Female Organ Size Drug Effects Ovary Rats Uterus Journal Article Research Support, Non-u.s. Gov't Discipline Environmental Science Discipline Environmental Chemistry
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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