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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Astalan, Andrea Prieto Oisjöen, Fredrik Winkler, Dag Kalabukhov, Alexey Schneiderman, Justin F. Johansson, Christer |
| Description | Country affiliation: Sweden Author Affiliation: Oisjöen F ( Department of Microtechnology and Nanoscience-MC2, Chalmers University of Technology, Göteborg, Sweden. fredrik.oisjoen@chalmers.se) |
| Abstract | We demonstrate a one-step wash-free bioassay measurement system capable of tracking biochemical binding events. Our approach combines the high resolution of frequency- and high speed of time-domain measurements in a single device in combination with a fast one-step bioassay. The one-step nature of our magnetic nanoparticle (MNP) based assay reduces the time between sample extraction and quantitative results while mitigating the risks of contamination related to washing steps. Our method also enables tracking of binding events, providing the possibility of, for example, investigation of how chemical/biological environments affect the rate of a binding process or study of the action of certain drugs. We detect specific biological binding events occurring on the surfaces of fluid-suspended MNPs that modify their magnetic relaxation behavior. Herein, we extrapolate a modest sensitivity to analyte of 100 ng/ml with the present setup using our rapid one-step bioassay. More importantly, we determine the size-distributions of the MNP systems with theoretical fits to our data obtained from the two complementary measurement modalities and demonstrate quantitative agreement between them. |
| ISSN | 09565663 |
| Issue Number | 5 |
| Volume Number | 25 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-01-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biological Assay Instrumentation Immunomagnetic Separation Magnetics Nanoparticles Chemistry Nanotechnology Biosensing Techniques Equipment Design Equipment Failure Analysis Reproducibility Of Results Sensitivity And Specificity Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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