NDLI: An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates.

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An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates.

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An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eriksson, Mikaela Mandenius, Carl-Fredrik Åslund, Andreas K. O. Johansson, Leif B. G. Bergström, Gunnar Simon, Rozalyn Nilsson, K. Peter R. Heppner, Frank L. Prokop, Stefan
Description	Country affiliation: Sweden Author Affiliation: Johansson LB ( Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.); Simon R ( Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.); Bergström G ( Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.); Eriksson M ( Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.); Prokop S ( Department of Neuropathology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany.); Mandenius CF ( Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.); Heppner FL ( Department of Neuropathology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany.); Åslund AK ( Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.); Nilsson KP ( Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden. Electronic address: petni@ifm.liu.se.)
Abstract	Ligands for identifying protein aggregates are of great interest as such deposits are the pathological hallmark of a wide range of severe diseases including Alzheimer's and Parkinson's disease. Here we report the synthesis of an azide functionalized fluorescent pentameric oligothiophene that can be utilized as a ligand for multimodal detection of disease-associated protein aggregates. The azide functionalization allows for attachment of the ligand to a surface by conventional click chemistry without disturbing selective interaction with protein aggregates and the oligothiophene-aggregate interaction can be detected by fluorescence or surface plasmon resonance. In addition, a methodology where the oligothiophene ligand is employed as a capturing molecule selective for aggregated proteins in combination with an antibody detecting a distinct peptide/protein is also presented. We foresee that this methodology will offer the possibility to create a variety of multiplex sensing systems for sensitive and selective detection of protein aggregates, the pathological hallmarks of several neurodegenerative diseases.
ISSN	09565663
Volume Number	63
e-ISSN	18734235
Journal	Biosensors and Bioelectronics
Language	English
Publisher	Elsevier
Publisher Date	2015-01-15
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Azides Chemistry Protein Array Analysis Instrumentation Protein Interaction Mapping Thiophenes Complex Mixtures Equipment Design Equipment Failure Analysis Ligands Spectrometry, Fluorescence Surface Plasmon Resonance Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry

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