NDLI: An electrochemical immunosensor for ultrasensitive detection of carbohydrate antigen 199 based on Au@Cu(x)OS yolk-shell nanostructures with porous shells as labels.

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An electrochemical immunosensor for ultrasensitive detection of carbohydrate antigen 199 based on Au@Cu(x)OS yolk-shell nanostructures with porous shells as labels.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Yueyun Guo, Aiping Meng, Xianchao Wei, Qin Cao, Wei Du, Bin Wu, Dan
Description	Author Affiliation: Guo A ( Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong (University of Jinan), School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.); Li Y ( School of Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China.); Cao W ( Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong (University of Jinan), School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.); Meng X ( Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong (University of Jinan), School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.); Wu D ( Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong (University of Jinan), School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.); Wei Q ( Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong (University of Jinan), School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China. Electronic address: sdjndxwq@163.com.); Du B ( Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong (University of Jinan), School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.)
Abstract	A novel and sensitive electrochemical immunosensor for ultrasensitive detection of pancreatic cancer biomarker carbohydrate antigen 199 (CA199) was proposed by using Au@Cu(x)OS yolk-shell nanostructures with porous shells as labels for signal amplification. Au@Cu(x)OS yolk-shell nanostructures exhibit high electrocatalytic activity toward the reduction of hydrogen peroxide (H2O2) as analytical signal. Moreover, secondary antibody (Ab2) can adsorb on the surface of Au@Cu(x)OS with porous shells which has large surface area and could greatly increase the probability of Ab2-antigen interactions thereby leading to higher sensitivity. Reduced graphene oxide-tetraethylene pentamine (rGO-TEPA), containing abundant amine groups, was supported Au nanoparticles as a support platform to immobilize the primary antibody (Ab1). The resulting sensing interface of rGO-TEPA/AuNPs could provide a large electroconductive surface area, allowing high loadings of the biological recognition elements as well as the occurrence of electrocatalytic and electron-transfer processes. Under optimal conditions, the immunosensor exhibited a wide linear response to CA199 ranging from 0.001 to 12 U/mL with a low detection limit of 0.0005 U/mL. The designed immunosensor displayed good precision, high sensitivity, acceptable stability and reproducibility, and has been applied to the analysis of serum with satisfactory results. The proposed method provides a new promising platform of clinical immunoassay for other biomolecules.
ISSN	09565663
Volume Number	63
e-ISSN	18734235
Journal	Biosensors and Bioelectronics
Language	English
Publisher	Elsevier
Publisher Date	2015-01-15
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antigens, Tumor-associated, Carbohydrate Isolation & Purification Tumor Markers, Biological Biosensing Techniques Methods Metal Nanoparticles Chemistry Blood Gold Graphite Humans Hydrogen Peroxide Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry

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