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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Govindhan, Maduraiveeran Amiri, Mona Chen, Aicheng |
| Description | Author Affiliation: Govindhan M ( Department of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, ON, Canada P7B 5E1.); Amiri M ( Department of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, ON, Canada P7B 5E1.); Chen A ( Department of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, ON, Canada P7B 5E1. Electronic address: aicheng.chen@lakeheadu.ca.) |
| Abstract | Here we report on a facile, rapid, sensitive, selective and highly stable electrochemical sensing platform for ß-nicotinamide adenine dinucleotide (NADH) based on uncapped Au nanoparticle/reduced graphene oxide (rGO) nanocomposites without the aid of any redox mediators and enzymes. The Au nanoparticle/rGO composite sensing platform was directly formed on a glassy carbon electrode through an in situ electrochemical reduction of GO and Au(3+) with a 100% usage of the precursors. The as-prepared Au nanoparticle/rGO composites demonstrated excellent direct electrocatalytic oxidation toward NADH, providing a large electrochemical active surface area as well as a favorable environment for electron transfer from NADH to the electrode via the enhanced mobility of charge carriers. The Au nanoparticle/rGO composites offered a ~2.3 times higher electrocatalytic current density with a negative shift of 112mV, in comparison to Au nanoparticles. The sensor developed in this study displayed a high sensitivity of 0.916µA/µMcm(2) and a wide linear range of from 50nM to 500µM with a limit of detection of 1.13nM (S/N=3). The interferences from the common interferents such as glutathione, glucose, ascorbic acid and quanine were negligible. The prepared sensor was further tested for the determination of NADH in human urine samples, showing the Au nanoparticle/rGO nanocomposites simultaneously formed by one-step electrochemical reduction have promising biomedical applications. |
| ISSN | 09565663 |
| Volume Number | 66 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-04-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Methods Nad Urine Statistics & Numerical Data Electrochemical Techniques Gold Graphite Humans Metal Nanoparticles Ultrastructure Microscopy, Electron, Scanning Nanocomposites Oxidation-reduction Reproducibility Of Results Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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