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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Li, He Tan, Lei Feng, Liming Tang, Youwen Xu, Zhiguang Shen, Guixian |
| Description | Country affiliation: China Author Affiliation: Feng L ( School of Chemistry and Environment, MOE Key Laboratory of Laser Life Science, South China Normal University, 510006 Guangzhou, China.); Tan L ( School of Chemistry and Environment, MOE Key Laboratory of Laser Life Science, South China Normal University, 510006 Guangzhou, China); Li H ( School of Chemistry and Environment, MOE Key Laboratory of Laser Life Science, South China Normal University, 510006 Guangzhou, China.); Xu Z ( School of Chemistry and Environment, MOE Key Laboratory of Laser Life Science, South China Normal University, 510006 Guangzhou, China. Electronic address: tanglab@scnu.edu.cn.); Shen G ( School of Chemistry and Environment, MOE Key Laboratory of Laser Life Science, South China Normal University, 510006 Guangzhou, China.); Tang Y ( School of Chemistry and Environment, MOE Key Laboratory of Laser Life Science, South China Normal University, 510006 Guangzhou, China.) |
| Abstract | -amanitin could make patients die of acute liver failure within a short time if suitable treatment is not provided in a timely fashion. This paper demonstrates a new strategy for direct detection of -amanitin in serum using carbon quantum dots-embedded specificity determinant imprinted polymers. According to the structure of -amanitin, we selected a proper moiety of -amanitin as specificity determinant to synthesize template to prepare the MIPs. The computer simulation was used to screen out acidic methacrylic acid (MAA) and basic 4-vinyl pyridine (4-Vpy) together as functional monomers, and the experiments further proved that synergistic interaction of MAA and 4-Vpy was beneficial to enhance the recognition capability of MIPs for -amanitin. Moreover, the fluorescence intensity showed good linear correlations with the concentration of -amanitin from 0.05 to 4.0µgmL(-1). The detection limit for -amanitin was 15ngmL(-1). The nanoparticles were employed to directly detect -amanitin in serum without any pretreatment with recoveries of 97.8-100.9%. |
| ISSN | 09565663 |
| Volume Number | 69 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Alpha-amanitin Blood Coated Materials, Biocompatible Chemical Synthesis Molecular Imprinting Methods Polymers Chemistry Quantum Dots Spectrometry, Fluorescence Reproducibility Of Results Sensitivity And Specificity Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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