NDLI: Recent advances in nanoparticle based aptasensors for food contaminants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ragavan, K. V. Thakur, M. S. Sharma, Richa Raghavarao, K. S. M. S.
Description	Country affiliation: India Author Affiliation: Sharma R ( Department of Food Engineering, CSIR-CFTRI, India); Ragavan KV ( Department of Food Engineering, CSIR-CFTRI, India); Thakur MS ( Materials Science Centre, University of Mysore, Mysore 570005, Karnataka, India. Electronic address: msthakur@yahoo.com.); Raghavarao KS ( Department of Food Engineering, CSIR-CFTRI, India)
Abstract	Food safety and hazard analysis is a prime concern of human life, thus quality assessment of food and water is the need of the day. Recent advances in nano-biotechnology play a significant role in providing possible solutions for developing highly sensitive and affordable detection tools for food analysis. Nanomaterials based aptasensors hold great potential to overcome the drawbacks of conventional analytical techniques. Aptamers comprise a novel class of highly specific bio-recognition elements which are produced by SELEX (systematic evolution of ligands by exponential enrichment) process. They bind to target molecules by folding into 3D structures that can discriminate different chiral compounds. The flexibility in making modifications in aptamers contribute to the design of biosensors, enabling the generation of bio-recognition elements for a wide variety of target molecules. Nanomaterials such as metal nanoparticles, metal nanoclusters, metal oxide nanoparticles, metal and carbon quantum dots, graphene, carbon nanotubes and nanocomposites enable higher sensitivity by signal amplification and introduce several novel transduction principles such as enhanced chemiluminescence, fluorescence, Raman signals, electrochemical signals, enhanced catalytic activity, and super-paramagnetic properties to the biosensor. Although there are a few reviews published recently which deal with the potential of aptamers in various fields, none are devoted exclusively to the potential of aptasensors based on nanomaterials for the analysis of food contaminants. Hence, the current review discusses several transduction systems and their principles used in aptamer based nanosensors which have been developed in the past five years, the challenges faced in their designing, along with their strengths and limitations.
ISSN	09565663
Volume Number	74
e-ISSN	18734235
Journal	Biosensors and Bioelectronics
Language	English
Publisher	Elsevier
Publisher Date	2015-12-15
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aptamers, Nucleotide Chemistry Biosensing Techniques Instrumentation Food Analysis Food Contamination Analysis Nanoconjugates Nanotechnology Equipment Design Equipment Failure Analysis Food Safety Methods Ultrastructure Journal Article Research Support, Non-u.s. Gov't Review Discipline Biotechnology
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry

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