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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lentini, Germana Allegra, Alessandro Musolino, Caterina Fazio, Enza Nicolò, Marco S. Carnazza, Santina Trusso, Sebastiano Guglielmino, Salvatore P. P. De Plano, Laura M. Neri, Fortunato Calabrese, Federica Franco, Domenico Puliafico, Maria |
| Description | Country affiliation: Italy Author Affiliation: Lentini G ( Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98158 Messina, Italy.); Fazio E ( Department of Physics and Earth Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98158 Messina, Italy.); Calabrese F ( Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98158 Messina, Italy.); De Plano LM ( Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98158 Messina, Italy.); Puliafico M ( Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98158 Messina, Italy.); Franco D ( Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98158 Messina, Italy.); Nicolò MS ( Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98158 Messina, Italy.); Carnazza S ( Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98158 Messina, Italy.); Trusso S ( CNR-IPCF Institute for Chemical-Physical Processes, Viale Ferdinando Stagno d'Alcontres 37, 98158 Messina, Italy.); Allegra A ( Department of General Surgery, Oncology and Pathological Anatomy, University of Messina, Via Consolare Valeria, 1, 98125 Messina, Italy. Electronic address: aallegra@unime.it.); Neri F ( Department of Physics and Earth Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98158 Messina, Italy.); Musolino C ( Department of General Surgery, Oncology and Pathological Anatomy, University of Messina, Via Consolare Valeria, 1, 98125 Messina, Italy.); Guglielmino SP ( Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98158 Messina, Italy.) |
| Abstract | The early diagnosis of malignancy is the most critical factor for patient survival and the treatment of cancer. In particular, leukemic cells are highly heterogeneous, and there is a need to develop new rapid and accurate detection systems for early diagnosis and monitoring of minimal residual disease. This study reports the utilization of molecular networks consisting of entire bacteriophage structure, displaying specific peptides, directly assembled with silver nanoparticles as a new Surface Enhanced Raman Spectroscopy (SERS) probe for U937 cells identification in vitro. A 9-mer pVIII M13 phage display library is screened against U937 to identify peptides that selectively recognize these cells. Then, phage clone is assembled with silver nanoparticles and the resulting network is used to obtain a SERS signal on cell-type specific molecular targets. The proposed strategy could be a very sensitive tool for the design of biosensors for highly specific and selective identification of hematological cancer cells and for detection of minimal residual disease in a significant proportion of human blood malignancy. |
| ISSN | 09565663 |
| Volume Number | 74 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-12-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Tumor Markers, Biological Metabolism Metal Nanoparticles Chemistry Neoplasms, Experimental Diagnosis Peptide Library Spectrum Analysis, Raman Instrumentation Humans Ultrastructure Molecular Probe Techniques Reproducibility Of Results Sensitivity And Specificity Silver Surface Plasmon Resonance U937 Cells Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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