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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tzakos, Andreas G. Chatzikonstantinou, Alexandra Katsoura, Maria H. Polydera, Angeliki C. Stamatis, Haralambos Papadopoulou, Athena A. Kyriakou, Eleni |
| Description | Country affiliation: Greece Author Affiliation: Papadopoulou AA ( Laboratory of Biotechnology, Department of Biological Applications and Technologies, University of Ioannina, University Campus, 45110 Ioannina, Greece.) |
| Abstract | The lipase-catalyzed molecular hybridization of -lipoic acid (LA) with bioactive compounds pyridoxine, tyrosol and tyramine was performed in ionic solvents and deep eutectic solvents. The biocatalytic reactions were catalyzed by Candida antarctica lipase B immobilized onto various functionalized multi-walled carbon nanotubes (f-CNTs-CaLB), as well as by commercial Novozym 435. The use of f-CNTs-CaLB leads, in most cases, to higher conversion yields as compared to Novozym 435. The nature and ion composition of ionic solvents affect the performance of the biocatalytic process. The highest conversion yield was observed in (mtoa)NTf2. The high enzyme stability and the relatively low solubility of substrates in specific media account for the improved biocatalytic synthesis of molecular hybrids of LA. Principal component analysis was used to screen for potential lipoxygenase inhibitors. In vitro studies showed that the synthesized compounds exhibit up to 10-fold increased inhibitory activity on lipoxygenase mediated lipid peroxidation as compared to parent molecules. |
| ISSN | 09608524 |
| Volume Number | 136 |
| e-ISSN | 18732976 |
| Journal | Bioresource Technology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Fungal Proteins Metabolism Lipase Phenylethyl Alcohol Analogs & Derivatives Pyridoxine Thioctic Acid Tyramine Antioxidants Pharmacology Ions Lipoxygenase Principal Component Analysis Solubility Drug Effects Solvents Soybeans Enzymology Journal Article Research Support, Non-u.s. Gov't Discipline Bioresource |
| Content Type | Text |
| Resource Type | Article |
| Subject | Waste Management and Disposal Medicine Environmental Engineering Renewable Energy, Sustainability and the Environment Bioengineering |
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