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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rose, B. Hyrc, K. |
| Description | Author Affiliation: Hyrc K ( Department of Physiology and Biophysics, University of Miami School of Medicine, Florida 33101.) |
| Abstract | The product of the viral src gene (v-src) is the protein tyrosine kinase pp60v-src. Among the known consequences of pp60v-src activity is the reduction in permeability of gap junctions, an effect that is counteracted by the calcium antagonist TMB-8 (8-N,N-[diethylamino]octyl- 3,4,5-trimethoxybenzoate). We show here that a decrease in intracellular pH (pHi) also counteracts the v-src effect: junctional permeability of cells containing active v-src kinase rose with decreasing pHi in the range 7.15 to 6.75, whereas junctional permeability of cells containing inactive v-src kinase or no v-src at all was insensitive to pH in that range. Low pH also counteracted the known action of diacylglycerol on junction, but only when pp60v-src kinase was inactive. Immunoblots of whole-cell lysates using an antibody against phosphotyrosine show that phosphorylation on tyrosine of at least one cellular protein, specific for pp60v-src kinase activity, was reduced by low pH but not by TMB-8. These results suggest that TMB-8 does not inhibit v-src action on junctional permeability by interfering with tyrosine phosphorylation of a protein crucial for closure of gap junction channels, but that the inhibition by low pH may be via this mechanism. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 4 |
| Volume Number | 110 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1990-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Membrane Permeability Intercellular Junctions Metabolism Oncogene Protein Pp60(v-src) Animals Avian Sarcoma Viruses Genetics Calcium Channel Blockers Pharmacology Cell Communication Drug Effects Cell Line Cell Transformation, Neoplastic Cells, Cultured Diglycerides Gallic Acid Analogs & Derivatives Gene Expression Hydrogen-Ion Concentration Kinetics Mice Mice, Inbred BALB C Mice, Inbred Strains Phosphorylation Protein-Tyrosine Kinases Temperature Tyrosine Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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