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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Burgeson, R. E. Marinkovich, M. P. Keene, D. R. Lunstrum, G. P. |
| Description | Author Affiliation: Marinkovich MP ( Shriner's Hospital for Crippled Children, Portland, Oregon.) |
| Abstract | We report the identification of a novel laminin variant that appears to be unique to a subset of epithelial basement membranes. The variant contains two chains electrophoretically and immunologically identical to the B1 and B2 chains. Epitopes contained in the laminin A chain are absent from the molecule, and a 190-kD chain substitutes for the A chain. V8 protease analysis and Western blotting studies indicate that the variant 190-kD chain shows structural and immunological similarity to the 200-kD chain of kalinin. Rotary shadowing analysis indicates that the 190-kD chain contributes a large globular structure to the variant long arm, but lacks the short arm contributed to laminin by the A chain. The variant is produced by cultured skin explants, human keratinocytes and a squamous cell carcinoma line, and is present in human amniotic fluid. Polyclonal antibodies raised to kalinin, a recently characterized novel component of anchoring filaments, and mAb BM165 which recognizes a subunit of kalinin (Rousselle et al., 1991) cross react with the variant under nonreducing conditions. Immunohistological surveys of human tissues using the crossreacting antikalinin antiserum indicate that the distribution of this laminin variant is at least restricted to anchoring filament containing basement membranes. We propose the name K-laminin for this variant. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 119 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1992-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Epidermis Cytology Genetic Variation Keratinocytes Laminin Genetics Skin Basement Membrane Chemistry Ultrastructure Blotting, Western Cells, Cultured Cross Reactions Epitopes Infant, Newborn Immunology Macromolecular Substances Molecular Weight Organ Specificity Peripheral Nerves Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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