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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ward, J. Franzini-armstrong, C. Hong, L. Elbl, T. Rybicka, K. K. Gatewood, B. K. Baillie, D. L. Bucher, E. A. |
| Description | Author Affiliation: Hong L ( Department of Cell and Developmental Biology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.) |
| Abstract | Tissue functions and mechanical coupling of cells must be integrated throughout development. A striking example of this coupling is the interactions of body wall muscle and hypodermal cells in Caenorhabditis elegans. These tissues are intimately associated in development and their interactions generate structures that provide a continuous mechanical link to transmit muscle forces across the hypodermis to the cuticle. Previously, we established that mup-4 is essential in embryonic epithelial (hypodermal) morphogenesis and maintenance of muscle position. Here, we report that mup-4 encodes a novel transmembrane protein that is required for attachments between the apical epithelial surface and the cuticular matrix. Its extracellular domain includes epidermal growth factor-like repeats, a von Willebrand factor A domain, and two sea urchin enterokinase modules. Its intracellular domain is homologous to filaggrin, an intermediate filament (IF)-associated protein that regulates IF compaction and that has not previously been reported as part of a junctional complex. MUP-4 colocalizes with epithelial hemidesmosomes overlying body wall muscles, beginning at the time of embryonic cuticle maturation, as well as with other sites of mechanical coupling. These findings support that MUP-4 is a junctional protein that functions in IF tethering, cell–matrix adherence, and mechanical coupling of tissues. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 154 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2001-07-23 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Caenorhabditis Elegans Proteins Caenorhabditis Elegans Metabolism Cell Adhesion Molecules Epithelial Cells Animals Animals, Genetically Modified Embryology Growth & Development Cell Adhesion Physiology Genetics Cloning, Molecular Embryo, Nonmammalian Cytology Gene Expression Drug Effects Green Fluorescent Proteins Helminth Proteins Hemidesmosomes Larva Ultrastructure Luminescent Proteins Membrane Proteins Molecular Sequence Data Muscles Mutation Organ Specificity Physical Chromosome Mapping RNA, Double-Stranded Pharmacology Sequence Analysis, DNA Sequence Homology, Amino Acid Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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