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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Müller, U. Linton, J. Schmidt, A. Wang, D. Brandenberger, R. Backus, C. Denda, S. Reichardt, L. F. |
| Description | Author Affiliation: Brandenberger R ( Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA.) |
| Abstract | The epithelial–mesenchymal interactions required for kidney organogenesis are disrupted in mice lacking the integrin α8β1. None of this integrin's known ligands, however, appears to account for this phenotype. To identify a more relevant ligand, a soluble integrin α8β1 heterodimer fused to alkaline phosphatase (AP) has been used to probe blots and cDNA libraries. In newborn mouse kidney extracts, α8β1-AP detects a novel ligand of 70–90 kD. This protein, named nephronectin, is an extracellular matrix protein with five EGF-like repeats, a mucin region containing a RGD sequence, and a COOH-terminal MAM domain. Integrin α8β1 and several additional RGD-binding integrins bind nephronectin. Nephronectin mRNA is expressed in the ureteric bud epithelium, whereas α8β1 is expressed in the metanephric mesenchyme. Nephronectin is localized in the extracellular matrix in the same distribution as the ligand detected by α8β1-AP and forms a complex with α8β1 in vivo. Thus, these results strongly suggest that nephronectin is a relevant ligand mediating α8β1 function in the kidney. Nephronectin is expressed at numerous sites outside the kidney, so it may also have wider roles in development. The approaches used here should be generally useful for characterizing the interactions of novel extracellular matrix proteins identified through genomic sequencing projects. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 154 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2001-07-23 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Extracellular Matrix Proteins Genetics Metabolism Kidney Receptors, Antigen Alkaline Phosphatase Animals Animals, Newborn Cloning, Molecular Extracellular Matrix Chemistry K562 Cells Embryology Ligands Macromolecular Substances Mesoderm Mice Molecular Sequence Data Oligopeptides Organ Specificity Protein Binding Physiology RNA, Messenger Biosynthesis Recombinant Fusion Proteins Repetitive Sequences, Amino Acid Sequence Analysis, DNA Sequence Homology, Amino Acid Ureter Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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