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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kléber, Maurice Hari, Lisette Paratore, Christian Suter, Ueli Brault, Véronique Kemler, Rolf Sommer, Lukas Ille, Fabian Leimeroth, Rainer Lee, Hye-youn |
| Description | Author Affiliation: Hari L ( Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH-8093 Zurich, Switzerland.) |
| Abstract | β-Catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream signaling component of Wnt that controls multiple developmental processes such as cell proliferation, apoptosis, and fate decisions. To study the role of β-catenin in neural crest development, we used the Cre/loxP system to ablate β-catenin specifically in neural crest stem cells. Although several neural crest–derived structures develop normally, mutant animals lack melanocytes and dorsal root ganglia (DRG). In vivo and in vitro analyses revealed that mutant neural crest cells emigrate but fail to generate an early wave of sensory neurogenesis that is normally marked by the transcription factor neurogenin (ngn) 2. This indicates a role of β-catenin in premigratory or early migratory neural crest and points to heterogeneity of neural crest cells at the earliest stages of crest development. In addition, migratory neural crest cells lateral to the neural tube do not aggregate to form DRG and are unable to produce a later wave of sensory neurogenesis usually marked by the transcription factor ngn1. We propose that the requirement of β-catenin for the specification of melanocytes and sensory neuronal lineages reflects roles of β-catenin both in Wnt signaling and in mediating cell–cell interactions. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 159 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2002-12-09 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cytoskeletal Proteins Physiology Neural Crest Embryology Trans-Activators Animals Basic Helix-Loop-Helix Transcription Factors Biological Markers Cell Communication Cell Differentiation Cell Lineage Cells, Cultured Crosses, Genetic Genetics Ganglia, Spinal Cytology Gene Expression Regulation, Developmental Gene Silencing Helix-Loop-Helix Motifs Melanocytes Mice Mice, Mutant Strains Models, Biological Nerve Tissue Proteins Metabolism Neuroglia Neurons RNA, Messenger Recombination, Genetic Stem Cells Beta Catenin Comparative Study Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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