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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ekert, Paul G. Baliga, Belinda C. Kumar, Sharad Vaux, David L. Read, Stuart H. |
| Description | Author Affiliation: Read SH ( Hanson Institute, Adelaide, Australia 5000.) |
| Abstract | CVaspase activation is a key event in apoptosis execution. In stress-induced apoptosis, the mitochondrial pathway of caspase activation is believed to be of central importance. In this pathway, cytochrome c released from mitochondria facilitates the formation of an Apaf-1 apoptosome that recruits and activates caspase-9. Recent data indicate that in some cells caspase-9 may not be the initiator caspase in stress-mediated apoptosis because caspase-2 is required upstream of mitochondria for the release of cytochrome c and other apoptogenic factors. To determine how caspase-2 is activated, we have studied the formation of a complex that mediates caspase-2 activation. Using gel filtration analysis of cell lysates, we show that caspase-2 is spontaneously recruited to a large protein complex independent of cytochrome c and Apaf-1 and that recruitment of caspase-2 to this complex is sufficient to mediate its activation. Using substrate-binding assays, we also provide the first evidence that caspase-2 activation may occur without processing of the precursor molecule. Our data are consistent with a model where caspase-2 activation occurs by oligomerization, independent of the Apaf-1 apoptosome. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 159 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2002-12-09 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Apoptosis Caspases Physiology Proteins Animals Apoptotic Protease-Activating Factor 1 Caspase 2 Metabolism Cell Extracts Cell Line Cytochrome c Group Enzyme Activation Green Fluorescent Proteins HeLa Cells Kinetics Luminescent Proteins Macromolecular Substances Mice Mice, Knockout Models, Biological Molecular Weight Myeloid Cells Potassium Chloride Pharmacology Genetics Recombinant Fusion Proteins Sodium Chloride Time Factors Tumor Cells, Cultured Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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