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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nakao, Shinsuke Hirano, Shinji Takeichi, Masatoshi Platek, Anna |
| Description | Author Affiliation: Nakao S ( Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.) |
| Abstract | OL-protocadherin (OL-pc) is a transmembrane protein belonging to the cadherin superfamily, which has been shown to accumulate at cell–cell contacts via its homophilic interaction, but its molecular roles remain elusive. In this study, we show that OL-pc bound Nck-associated protein 1 (Nap1), a protein that regulates WAVE-mediated actin assembly. In astrocytoma U251 cells not expressing OL-pc, Nap1 was localized only along the lamellipodia. However, exogenous expression of OL-pc in these cells recruited Nap1 as well as WAVE1 to cell–cell contact sites. Although OL-pc expression had no effect on the motility of solitary U251 cells, it accelerated their movement when they were in contact with one another, causing concomitant reorganization of F-actin and N-cadherin at cell junctions. OL-pc mutants lacking the Nap1-binding site exhibited no such effect. N-cadherin knockdown mimicked OL-pc expression in enhancing cell movement. These results suggest that OL-pc remodels the motility and adhesion machinery at cell junctions by recruiting the Nap1–WAVE1 complex to these sites and, in turn, promotes the migration of cells. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 182 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2008-07-28 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cadherins Metabolism Cell Communication Physiology Cell Membrane Cell Movement Proteins Actins Animals Antigens, CD Genetics COS Cells Cell Adhesion Cell Line, Tumor Cercopithecus Aethiops Intercellular Junctions Pseudopodia Wiskott-Aldrich Syndrome Protein Family Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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