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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cao, Jian Riggs, Blake Field, Christine M. Albertson, Roger Sullivan, William |
| Description | Author Affiliation: Cao J ( Sinsheimer Laboratories, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.) |
| Abstract | Plasma membrane ingression during cytokinesis involves both actin remodeling and vesicle-mediated membrane addition. Vesicle-based membrane delivery from the recycling endosome (RE) has an essential but ill-defined involvement in cytokinesis. In the Drosophila melanogaster early embryo, Nuf (Nuclear fallout), a Rab11 effector which is essential for RE function, is required for F-actin and membrane integrity during furrow ingression. We find that in nuf mutant embryos, an initial loss of F-actin at the furrow is followed by loss of the associated furrow membrane. Wild-type embryos treated with Latrunculin A or Rho inhibitor display similar defects. Drug- or Rho-GTP–induced increase of actin polymerization or genetically mediated decrease of actin depolymerization suppresses the nuf mutant F-actin and membrane defects. We also find that RhoGEF2 does not properly localize at the furrow in nuf mutant embryos and that RhoGEF2–Rho1 pathway components show strong specific genetic interactions with Nuf. We propose a model in which RE-derived vesicles promote furrow integrity by regulating the rate of actin polymerization through the RhoGEF2–Rho1 pathway. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 182 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2008-07-28 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Actins Metabolism Cytokinesis Physiology Drosophila Proteins Drosophila Melanogaster Embryology Embryo, Nonmammalian Nuclear Proteins Rab GTP-Binding Proteins Actin Cytoskeleton Ultrastructure Animals Cell Membrane Structures Genetics Cytoplasmic Vesicles Embryonic Development Guanine Nucleotide Exchange Factors Mutation Polymers Protein Synthesis Inhibitors Pharmacology Rho Guanine Nucleotide Exchange Factors Signal Transduction Rho GTP-Binding Proteins Research Support, N.I.H., Extramural Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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