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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hachey, Stephanie J. Strome, Susan Updike, Dustin L. Kreher, Jeremy |
| Description | Author Affiliation: Updike DL ( Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.) |
| Abstract | The immortal and totipotent properties of the germ line depend on determinants within the germ plasm. A common characteristic of germ plasm across phyla is the presence of germ granules, including P granules in Caenorhabditis elegans, which are typically associated with the nuclear periphery. In C. elegans, nuclear pore complex (NPC)–like FG repeat domains are found in the VASA-related P-granule proteins GLH-1, GLH-2, and GLH-4 and other P-granule components. We demonstrate that P granules, like NPCs, are held together by weak hydrophobic interactions and establish a size-exclusion barrier. Our analysis of intestine-expressed proteins revealed that GLH-1 and its FG domain are not sufficient to form granules, but require factors like PGL-1 to nucleate the localized concentration of GLH proteins. GLH-1 is necessary but not sufficient for the perinuclear location of granules in the intestine. Our results suggest that P granules extend the NPC environment in the germ line and provide insights into the roles of the PGL and GLH family proteins. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 192 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2011-03-21 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Caenorhabditis Elegans Proteins Metabolism Caenorhabditis Elegans Cytology Cytoplasmic Granules DEAD-box RNA Helicases Germ Cells RNA-Binding Proteins Animals Genetics Protein Structure, Tertiary Recombinant Fusion Proteins Research Support, N.I.H., Extramural Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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