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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jain, Rajan Wang, Qiaohong Leboeuf, Matthew R. Takeda, Norifumi Lu, Min Min Epstein, Jonathan A. |
| Description | Author Affiliation: Takeda N ( Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.) |
| Abstract | Intestinal epithelial stem cell identity and location have been the subject of substantial research. Cells in the +4 niche are slow-cycling and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by crypt base columnar (CBC) cells. CBCs are distinct from +4 cells, and the relationship between them is unknown, though both give rise to all intestinal epithelial lineages. We demonstrate that Hopx, an atypical homeobox protein, is a specific marker of +4 cells. Hopx-expressing cells give rise to CBCs and all mature intestinal epithelial lineages. Conversely, CBCs can give rise to +4 Hopx-positive cells. These findings demonstrate a bidirectional lineage relationship between active and quiescent stem cells in their niches. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 6061 |
| Volume Number | 334 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2011-12-09 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Epithelial Cells Cytology Intestinal Mucosa Intestine, Small Multipotent Stem Cells Stem Cell Niche Animals Cell Cycle Cell Differentiation Cell Lineage Cell Proliferation Cells, Cultured Homeodomain Proteins Genetics Drug Effects Mice Models, Biological Physiology Paneth Cells Tamoxifen Pharmacology Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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