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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bosch-marce, Marta Semenza, Gregg L. Gonzalez, Frank J. Zhang, Huafeng Wesley, Jacob B. Baek, Jin Hyen Tan, Yee Sun Shimoda, Larissa A. |
| Description | Author Affiliation: Zhang H ( Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.) |
| Abstract | Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 16 |
| Volume Number | 283 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2008-04-18 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Autophagy Hypoxia-Inducible Factor 1 Metabolism Anoxia Mitochondria Animals Apoptosis Regulatory Proteins Cell Death Cytoplasm Membrane Proteins Biosynthesis Mice Mice, Knockout Microtubule-Associated Proteins Mitochondrial Proteins Models, Biological Molecular Conformation Proteins Reactive Oxygen Species Research Support, N.I.H., Extramural Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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