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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Samaras, Susan Artner, Isabella Henderson, Eva Hang, Yan Vanhoose, Amanda M. Stein, Roland |
| Description | Author Affiliation: Vanhoose AM ( Department of Molecular Physiology and Biophysics, Vanderbilt Medical School, Nashville, Tennessee 37232, USA.) |
| Abstract | Pancreatic-duodenal homeobox factor-1 (Pdx1) is highly enriched in islet β cells and integral to proper cell development and adult function. Of the four conserved 5′-flanking sequence blocks that contribute to transcription in vivo, Area II (mouse base pairs -2153/-1923) represents the only mammalian specific control domain. Here we demonstrate that regulation of β-cell-enriched Pdx1 expression by the MafA and MafB transcription factors is exclusively through Area II. Thus, these factors were found to specifically activate through Area II in cell line transfection-based assays, and MafA, which is uniquely expressed in adult islet β cells was only bound to this region in quantitative chromatin immunoprecipitation studies. MafA and MafB are produced in β cells during development and were both bound to Area II at embryonic day 18.5. Expression of a transgene driven by Pdx1 Areas I and II was also severely compromised during $insulin^{+}$ cell formation in $MafB^{-/-}$ mice, consistent with the importance of this large Maf in β-cell production and Pdx1 expression. These findings illustrate the significance of large Maf proteins to Pdx1 expression in β cells, and in particular MafB during pancreatic development. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 33 |
| Volume Number | 283 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2008-08-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Homeodomain Proteins Genetics Insulin-Secreting Cells Physiology Maf Transcription Factors, Large Trans-Activators Transcription, Genetic 3T3 Cells Animals DNA Chemistry Genes, Reporter HeLa Cells Insulinoma Kidney Mice Molecular Sequence Data Pancreatic Neoplasms Promoter Regions, Genetic Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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