NDLI: Structure of long telomeric RNA transcripts: the G-rich RNA forms a compact repeating structure containing G-quartets.

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Structure of long telomeric RNA transcripts: the G-rich RNA forms a compact repeating structure containing G-quartets.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Randall, Adrian Griffith, Jack D.
Description	Author Affiliation: Randall A ( Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.)
Abstract	Recent studies have identified RNA transcripts arising from mammalian telomeres with the transcript of the C-rich strand (r(5'-UUAGGG-3')(n)) being much more abundant than transcripts of the G-rich strand. Here we used transmission electron microscopy, CD, and nuclease digestion to investigate the structure of approximately 640-nucleotide (nt) RNA transcripts of the C-rich and G-rich strands of mammalian telomeric DNA. The CD spectrum of the C-rich RNA in low salt (10 mm KCl) or high salt (100 mm KCl) was typical of mixed sequence RNA, whereas the CD spectrum for the G-rich RNA differed with changes characteristic of parallel G-quadruplexes at the higher salt concentration. Electron microscopy visualization of the C-rich RNA revealed relatively extended unstructured molecules 59.7 +/- 17.8 nm in length and with a width consistent with single-stranded RNA following metal coating. In contrast, the G-rich RNA was observed as round particles and short, thick rods with the rods being most prevalent in high salt conditions and absent in low salt. The rods were 22.7 +/- 4.8 nm in length and 7.6 nm in width. Digestion of the G-rich RNA with T1 RNA nuclease revealed a ladder of bands whose sizes were integral multiples of 24 nt plus a 4-nt overhang. These observations suggest a model in which G-rich telomeric RNA folds into chains of particles each consisting of four (UUAGGG) repeats stabilized by parallel G-quartets and joined by UUA linkers. These chains further condense to form short rods and round particles.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	21
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2009-05-22
Publisher Place	United States
Access Restriction	Open
Subject Keyword	G-Quadruplexes RNA Chemistry Telomere Circular Dichroism Models, Molecular Molecular Sequence Data Plasmids Genetics Ultrastructure RNA, Messenger Repetitive Sequences, Nucleic Acid Ribonuclease T1 Metabolism Research Support, N.I.H., Extramural Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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