NDLI: DNA adducts of antitumor cisplatin preclude telomeric sequences from forming G quadruplexes.

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DNA adducts of antitumor cisplatin preclude telomeric sequences from forming G quadruplexes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Heringova, Pavla Kasparkova, Jana Brabec, Viktor
Description	Country affiliation: Czech Republic Author Affiliation: Heringova P ( Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.)
Abstract	We studied the effect of antitumor cisplatin and inefficient transplatin on the structure and stability of G quadruplexes formed by the model human telomere sequence 5'-GGG(TTAGGG)(3)-3' using circular dichroism, UV-monitored thermal denaturation, and gel electrophoresis. In addition, to investigate whether there is a connection between the ability of cisplatin or transplatin to affect telomerase activity and stability of G quadruplexes, we also used a modified telomere repeat amplification protocol assay that uses an oligonucleotide substrate for telomerase elongation susceptible to forming a G quadruplex. The results indicate that cisplatin is more efficient than transplatin in disturbing the quadruplex structure, thereby precluding telomeric sequences from forming quadruplexes. On the other hand, the results of this work also demonstrate that in absence of free platinum complex, DNA adducts of antitumor cisplatin inhibit telomerase catalysis, so the mechanism underlying this inhibition does not involve formation of the G quadruplexes which are not elongated by telomerase.
File Format	HTM / HTML
ISSN	09498257
Issue Number	6
Volume Number	14
e-ISSN	14321327
Journal	JBIC Journal of Biological Inorganic Chemistry
Language	English
Publisher	Springer
Publisher Date	2009-08-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Antineoplastic Agents Pharmacology Cisplatin Chemistry Dna Adducts Drug Effects Metabolism G-quadruplexes Telomere Genetics Base Sequence Biocatalysis Circular Dichroism Electrophoresis, Polyacrylamide Gel Humans Nucleic Acid Amplification Techniques Nucleic Acid Denaturation Spectrophotometry, Ultraviolet Telomerase Antagonists & Inhibitors Transition Temperature Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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