NDLI: Widespread Distribution of Cell Defense against d-Aminoacyl-tRNAs

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Widespread Distribution of Cell Defense against d-Aminoacyl-tRNAs

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Widespread Distribution of Cell Defense against d-Aminoacyl-tRNAs

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wydau, Sandra Van Der Rest, Guillaume Aubard, Caroline Plateau, Pierre Blanquet, Sylvain
Description	Author Affiliation: Wydau S ( Laboratoire de Biochimie and Laboratoire des Mécanismes Réactionnels, Ecole Polytechnique, CNRS, 91128 Palaiseau Cedex, France.)
Abstract	Several l-aminoacyl-tRNA synthetases can transfer a d-amino acid onto their cognate tRNA(s). This harmful reaction is counteracted by the enzyme d-aminoacyl-tRNA deacylase. Two distinct deacylases were already identified in bacteria (DTD1) and in archaea (DTD2), respectively. Evidence was given that DTD1 homologs also exist in nearly all eukaryotes, whereas DTD2 homologs occur in plants. On the other hand, several bacteria, including most cyanobacteria, lack genes encoding a DTD1 homolog. Here we show that Synechocystis sp. PCC6803 produces a third type of deacylase (DTD3). Inactivation of the corresponding gene (dtd3) renders the growth of Synechocystis sp. hypersensitive to the presence of d-tyrosine. Based on the available genomes, DTD3-like proteins are predicted to occur in all cyanobacteria. Moreover, one or several dtd3-like genes can be recognized in all cellular types, arguing in favor of the nearubiquity of an enzymatic function involved in the defense of translational systems against invasion by d-amino acids.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	21
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2009-05-22
Publisher Place	United States
Access Restriction	Open
Subject Keyword	RNA, Transfer, Amino Acyl Metabolism Synechocystis Cytology Enzymology Aminoacyltransferases Genetics Isolation & Purification Biocatalysis Drug Effects Chromosomes, Bacterial Complex Mixtures Escherichia Coli Growth & Development Gene Silencing Genes, Bacterial Ions Pharmacology Phylogeny Sequence Homology, Amino Acid Substrate Specificity Tyrosine Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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