NDLI: Integration and long distance axonal regeneration in the central nervous system from transplanted primitive neural stem cells.

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Integration and long distance axonal regeneration in the central nervous system from transplanted primitive neural stem cells.

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Integration and long distance axonal regeneration in the central nervous system from transplanted primitive neural stem cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhao, Jiagang Li, Wenlin Zhang, Liangfang Ouyang, Hong Lin, Ying Liu, Yizhi Sun, Woong Lu, Paul Zhang, Kang Do, Jiun Ding, Sheng Cho, Hyo Min
Description	Author Affiliation: Zhao J ( State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510275, China.)
Abstract	Spinal cord injury (SCI) results in devastating motor and sensory deficits secondary to disrupted neuronal circuits and poor regenerative potential. Efforts to promote regeneration through cell extrinsic and intrinsic manipulations have met with limited success. Stem cells represent an as yet unrealized therapy in SCI. Recently, we identified novel culture methods to induce and maintain primitive neural stem cells (pNSCs) from human embryonic stem cells. We tested whether transplanted human pNSCs can integrate into the CNS of the developing chick neural tube and injured adult rat spinal cord. Following injection of pNSCs into the developing chick CNS, pNSCs integrated into the dorsal aspects of the neural tube, forming cell clusters that spontaneously differentiated into neurons. Furthermore, following transplantation of pNSCs into the lesioned rat spinal cord, grafted pNSCs survived, differentiated into neurons, and extended long distance axons through the scar tissue at the graft-host interface and into the host spinal cord to form terminal-like structures near host spinal neurons. Together, these findings suggest that pNSCs derived from human embryonic stem cells differentiate into neuronal cell types with the potential to extend axons that associate with circuits of the CNS and, more importantly, provide new insights into CNS integration and axonal regeneration, offering hope for repair in SCI.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	1
Volume Number	288
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2013-01-04
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Axons Metabolism Central Nervous System Gene Expression Regulation, Developmental Nerve Regeneration Neural Stem Cells Cytology Animals Cell Survival Cell Transplantation Chick Embryo Embryonic Stem Cells Green Fluorescent Proteins Immunohistochemistry Neural Tube Spinal Cord Injuries Therapy Stem Cells Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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