NDLI: Identification of a novel site in the tail of dynein heavy chain important for dynein function in vivo.

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2013 Volume: 288

Year: 2013 Volume: 288 Issue: 52

Year: 2013 Volume: 288 Issue: 51

Year: 2013 Volume: 288 Issue: 50

Year: 2013 Volume: 288 Issue: 49

Year: 2013 Volume: 288 Issue: 48

Year: 2013 Volume: 288 Issue: 47

Year: 2013 Volume: 288 Issue: 46

Year: 2013 Volume: 288 Issue: 45

Year: 2013 Volume: 288 Issue: 44

Year: 2013 Volume: 288 Issue: 43

Year: 2013 Volume: 288 Issue: 42

Year: 2013 Volume: 288 Issue: 41

Year: 2013 Volume: 288 Issue: 40

Year: 2013 Volume: 288 Issue: 39

Year: 2013 Volume: 288 Issue: 38

Year: 2013 Volume: 288 Issue: 37

Year: 2013 Volume: 288 Issue: 36

Year: 2013 Volume: 288 Issue: 35

Year: 2013 Volume: 288 Issue: 34

Year: 2013 Volume: 288 Issue: 33

Year: 2013 Volume: 288 Issue: 32

Year: 2013 Volume: 288 Issue: 31

Year: 2013 Volume: 288 Issue: 30

Year: 2013 Volume: 288 Issue: 29

Year: 2013 Volume: 288 Issue: 28

Year: 2013 Volume: 288 Issue: 27

Year: 2013 Volume: 288 Issue: 26

Year: 2013 Volume: 288 Issue: 25

Year: 2013 Volume: 288 Issue: 24

Year: 2013 Volume: 288 Issue: 23

Year: 2013 Volume: 288 Issue: 22

Year: 2013 Volume: 288 Issue: 21

Year: 2013 Volume: 288 Issue: 20

Year: 2013 Volume: 288 Issue: 19

Year: 2013 Volume: 288 Issue: 18

Year: 2013 Volume: 288 Issue: 17

Year: 2013 Volume: 288 Issue: 16

Year: 2013 Volume: 288 Issue: 15

Year: 2013 Volume: 288 Issue: 14

Year: 2013 Volume: 288 Issue: 13

Year: 2013 Volume: 288 Issue: 12

Year: 2013 Volume: 288 Issue: 11

Year: 2013 Volume: 288 Issue: 10

Year: 2013 Volume: 288 Issue: 9

Year: 2013 Volume: 288 Issue: 8

Year: 2013 Volume: 288 Issue: 7

Year: 2013 Volume: 288 Issue: 6

Year: 2013 Volume: 288 Issue: 5

Year: 2013 Volume: 288 Issue: 4

ngs (notochord granular surface) gene encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish.

Neuronal Per Arnt Sim (PAS) domain protein 4 (NPAS4) regulates neurite outgrowth and phosphorylation of synapsin I.

Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic ß cell death.

From macrophage interleukin-13 receptor to foam cell formation: mechanisms for Mß2 integrin interference.

The RAS guanyl nucleotide-releasing protein RasGRP1 is involved in lymphatic development in zebrafish.

Yeast eukaryotic initiation factor 4B (eIF4B) enhances complex assembly between eIF4A and eIF4G in vivo.

Insulin-degrading enzyme (IDE): a novel heat shock-like protein.

Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.

The native structure and composition of the cruciferin complex in Brassica napus.

Essential Role of Class II Phosphatidylinositol-3-kinase-C2α in Sphingosine 1-Phosphate Receptor-1-mediated Signaling and Migration in Endothelial Cells

Yeast Nab3 protein contains a self-assembly domain found in human heterogeneous nuclear ribonucleoprotein-C (hnRNP-C) that is necessary for transcription termination.

RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans.

Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.

A Specific and Essential Role for Na,K-ATPase α3 in Neurons Co-expressing α1 and α3

Cathepsin H Mediates the Processing of Talin and Regulates Migration of Prostate Cancer Cells

Biochemical evaluation of the decarboxylation and decarboxylation-deamination activities of plant aromatic amino acid decarboxylases.

Mechanism of action of Neisseria gonorrhoeae O-acetylpeptidoglycan esterase, an SGNH serine esterase.

The role of Î³-secretase activating protein (GSAP) and imatinib in the regulation of Î³-secretase activity and amyloid-ß generation.

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the $Inflammasome^{*}$

Structural determinants of ubiquitin conjugation in Entamoeba histolytica.

Evolution of broad spectrum ß-lactam resistance in an engineered metallo-ß-lactamase.

Toll-like Receptor Agonists and Febrile Range Hyperthermia Synergize to Induce Heat Shock Protein 70 Expression and Extracellular Release

Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons.

The V499G/Y501H mutation impairs fast motor kinetics of prestin and has significance for defining functional independence of individual prestin subunits.

ISG15 deregulates autophagy in genotoxin-treated ataxia telangiectasia cells.

Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling.

Chemical Genetic Screen Reveals a Role for Desmosomal Adhesion in Mammary Branching $Morphogenesis^{*}$

Identification of a novel site in the tail of dynein heavy chain important for dynein function in vivo.

Critical role of S1PR1 and integrin ß4 in HGF/c-Met-mediated increases in vascular integrity.

The viroporin activity of the minor structural proteins VP2 and VP3 is required for SV40 propagation.

The Dok-3/Grb2 Protein Signal Module Attenuates Lyn Kinase-dependent Activation of Syk Kinase in B Cell Antigen Receptor Microclusters

gln3 mutations dissociate responses to nitrogen limitation (nitrogen catabolite repression) and rapamycin inhibition of TorC1.

Identification of Drosophila and human 7-methyl GMP-specific nucleotidases.

The fidelity of transcription: RPB1 (RPO21) mutations that increase transcriptional slippage in S. cerevisiae.

Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb.

Isolation and characterization of RNA polymerase rpoB mutations that alter transcription slippage during elongation in Escherichia coli.

The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.

Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro.

Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in Dictyostelium.

Type 1 Inositol (1,4,5)-Trisphosphate Receptor Activates Ryanodine Receptor 1 to Mediate Calcium Spark Signaling in Adult Mammalian Skeletal Muscle

Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2.

Loss of LARGE2 disrupts functional glycosylation of -dystroglycan in prostate cancer.

Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein.

Mammalian Target of Rapamycin Complex 1 (mTORC1) Plays a Role in Pasteurella multocida Toxin (PMT)-induced Protein Synthesis and Proliferation in Swiss 3T3 Cells

Physcomitrella PpORS, basal to plant type III polyketide synthases in phylogenetic trees, is a very long chain 2'-oxoalkylresorcinol synthase.

Critical hydrogen bond formation for activation of the angiotensin II type 1 receptor.

The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells.

Multiple recognition motifs in nucleoporin Nup159 provide a stable and rigid Nup159-Dyn2 assembly.

The peroxisome proliferator-activated receptor Î³ coactivator 1 /ß (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells.

Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation.

Four of the Most Common Mutations in Primary Hyperoxaluria Type 1 Unmask the Cryptic Mitochondrial Targeting Sequence of Alanine:glyoxylate Aminotransferase Encoded by the Polymorphic Minor Allele

Sphingosine 1-Phosphate Receptor Signaling Regulates Proper Embryonic Vascular Patterning

Molecular Determinants of Subtype-selective Efficacies of Cytisine and the Novel Compound NS3861 at Heteromeric Nicotinic Acetylcholine Receptors

The LIM homeodomain transcription factor LHX6: a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis.

Transcriptional regulation patterns revealed by high resolution chromatin immunoprecipitation during cardiac hypertrophy.

Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1).

Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver.

Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.

ßIII spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex.

Disruption of ionic interactions between the nucleotide binding domain 1 (NBD1) and middle (M) domain in Hsp100 disaggregase unleashes toxic hyperactivity and partial independence from Hsp70.

A shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins.

SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells.

A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins.

Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.

Dual role of an N-terminal amyloidogenic mutation in apolipoprotein A-I: destabilization of helix bundle and enhancement of fibril formation.

Divergent molecular evolution of the mitochondrial sulfhydryl:cytochrome C oxidoreductase Erv in opisthokonts and parasitic protists.

ß3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation.

RapA2 is a calcium-binding lectin composed of two highly conserved cadherin-like domains that specifically recognize Rhizobium leguminosarum acidic exopolysaccharides.

FGF23 suppresses chondrocyte proliferation in the presence of soluble -Klotho both in vitro and in vivo.

ARHGAP21 protein, a new partner of -tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transition.

RYK is not mutated in autosomal dominant Robinow syndrome.

Reply to Mazzeu: Human mutations in RYK might cause Robinow syndrome.

Year: 2013 Volume: 288 Issue: 3

Year: 2013 Volume: 288 Issue: 2

Year: 2013 Volume: 288 Issue: 1

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2008 Volume: 283

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

Identification of a novel site in the tail of dynein heavy chain important for dynein function in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Qiu, Rongde Zhang, Jun Xiang, Xin
Description	Author Affiliation: Qiu R ( Department of Biochemistry and Molecular Biology, the Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA.)
Abstract	The minus end-directed microtubule motor cytoplasmic dynein is responsible for the intracellular movements of many organelles, including nuclei and endosomes. The dynein heavy chain contains a C-terminal motor domain and an N-terminal tail domain. The tail binds other dynein subunits and the cargo-interacting dynactin complex but is dispensable for movement of single dynein molecules in vitro. Here, we identified a mutation in the Aspergillus nidulans heavy chain tail domain, nudA(F208V), which causes obvious defects in dynein-mediated nuclear positioning and early endosome movement. Astonishingly, the nudA(F208I) mutation in the same position does not cause the same defects, suggesting that a subtle difference in the size of the amino acid side chain at this position has a significant consequence. Importantly, our biochemical analyses indicate that the nudA(F208V) mutation does not affect dynein subunit interactions and the mutant dynein is also able to bind dynactin and another dynein regulator, NUDF/LIS1. The mutant dynein is able to physically interact with the early endosome cargo, but dynein-mediated early endosome movement away from the hyphal tip occurs at a significantly reduced frequency. Within the small group of early endosomes that move away from the hyphal tip in the mutant, the average speed of movement is lower than that in the wild type. Given the dispensability of the dynein tail in dynein motility in vitro, our results support the notion that the structural integrity of the dynein tail is critical in vivo for the coordination of dynein force production and movement when the motor is heavily loaded.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	4
Volume Number	288
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2013-01-25
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dyneins Chemistry Physiology Amino Acid Sequence Aspergillus Nidulans Metabolism Binding Sites Cell Movement Cytoskeleton Endosomes Microtubules Models, Genetic Molecular Motor Proteins Molecular Sequence Data Mutation Phenotype Protein Binding Protein Structure, Tertiary Sequence Homology, Amino Acid Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in