NDLI: RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans.

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RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans.

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RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kimble, Judith Campbell, Zachary T. Anderson, Phil Wickens, Marvin Kroll-conner, Peggy Legendre, Jacqueline Baca
Description	Author Affiliation: LeGendre JB ( Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA.)
Abstract	The Staufen family consists of proteins that possess double-stranded RNA-binding domains (dsRBDs). Staufen proteins of Drosophila and mammals regulate mRNA localization, translation, and decay. We report analysis of Staufen in Caenorhabditis elegans, which we have designated STAU-1. We focus on its biochemical properties, mRNA targets, and possible role in RNAi. We show that STAU-1 is expressed as mRNA and protein at all stages of C. elegans development. The wild-type, full-length protein, purified from bacteria, binds duplex RNA with high affinity in vitro. Purified, mutant proteins lacking single dsRBDs still bind RNA efficiently, demonstrating that no single domain is required for binding to duplex RNA (although dsRBD2 could not be tested). STAU-1 mRNA targets were identified via immunoprecipitation with specific anti-STAU-1 antibodies, followed by microarray analysis (RIP-Chip). These studies define a set of 418 likely STAU-1 mRNA targets. Finally, we demonstrate that stau-1 mutants enhance exogenous RNAi and that stau-1;eri-1 double mutants exhibit sterility and synthetic germ line defects.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	4
Volume Number	288
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2013-01-25
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Caenorhabditis Elegans Proteins Chemistry RNA-Binding Proteins 3' Untranslated Regions Animals Biochemistry Caenorhabditis Elegans Physiology DNA, Complementary Metabolism Models, Biological Mutation Oligonucleotide Array Sequence Analysis Protein Binding RNA Interference RNA, Messenger Transgenes Two-Hybrid System Techniques Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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