NDLI: The death-inducer obliterator 1 (Dido1) gene regulates embryonic stem cell self-renewal.

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The death-inducer obliterator 1 (Dido1) gene regulates embryonic stem cell self-renewal.

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The death-inducer obliterator 1 (Dido1) gene regulates embryonic stem cell self-renewal.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lu, Weisi Songyang, Zhou Ouyang, Bin Liu, Yinyin Liang, Jiancong Kim, Hyeung Liu, Dan
Description	Author Affiliation: Liu Y ( From the Key Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-Sen University-Baylor College of Medicine Joint Research Center for Biomedical Sciences, School of Life Sciences and Key Laboratory of Reproductive Medicine of Guangdong Province, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China 510275, and.)
Abstract	The regulatory network of factors that center on master transcription factors such as Oct4, Nanog, and Sox2 help maintain embryonic stem (ES) cells and ensure their pluripotency. The target genes of these master transcription factors define the ES cell transcriptional landscape. In this study, we report our findings that Dido1, a target of canonical transcription factors such as Oct4, Sox2, and Nanog, plays an important role in regulating ES cell maintenance. We found that depletion of Dido1 in mouse ES cells led to differentiation, and ectopic expression of Dido1 inhibited differentiation induced by leukemia inhibitory factor withdrawal. We further demonstrated that whereas Nanog and Oct4 could occupy the Dido1 locus and promote its transcription, Dido1 could also target to the loci of pluripotency factors such as Nanog and Oct4 and positively regulate their expression. Through this feedback and feedforward loop, Dido1 is able to regulate self-renewal of mouse ES cells.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	8
Volume Number	289
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2014-02-21
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Genetics Embryonic Stem Cells Cytology Metabolism Transcription Factors Animals Cell Differentiation Drug Effects Cell Line Cell Proliferation Deficiency Feedback, Physiological Gene Expression Regulation Homeodomain Proteins Leukemia Inhibitory Factor Pharmacology Mice Octamer Transcription Factor-3 Pluripotent Stem Cells Promoter Regions, Genetic Protein Binding Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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