NDLI: Hydrogen Sulfide Suppresses Oxidized Low-density Lipoprotein (Ox-LDL)-stimulated Monocyte Chemoattractant Protein 1 generation from Macrophages via the Nuclear Factor κB (NF-κB) Pathway

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2014 Volume: 289 Issue: 52

Year: 2014 Volume: 289 Issue: 51

Year: 2014 Volume: 289 Issue: 50

Year: 2014 Volume: 289 Issue: 49

Year: 2014 Volume: 289 Issue: 48

Year: 2014 Volume: 289 Issue: 47

Year: 2014 Volume: 289 Issue: 46

Year: 2014 Volume: 289 Issue: 45

Year: 2014 Volume: 289 Issue: 44

Year: 2014 Volume: 289 Issue: 43

Year: 2014 Volume: 289 Issue: 42

Year: 2014 Volume: 289 Issue: 41

Year: 2014 Volume: 289 Issue: 40

Year: 2014 Volume: 289 Issue: 39

Year: 2014 Volume: 289 Issue: 38

Year: 2014 Volume: 289 Issue: 37

Year: 2014 Volume: 289 Issue: 36

Year: 2014 Volume: 289 Issue: 35

Year: 2014 Volume: 289 Issue: 34

Year: 2014 Volume: 289 Issue: 33

Year: 2014 Volume: 289 Issue: 32

Year: 2014 Volume: 289 Issue: 31

Year: 2014 Volume: 289 Issue: 30

Year: 2014 Volume: 289 Issue: 29

Year: 2014 Volume: 289 Issue: 28

Year: 2014 Volume: 289 Issue: 27

Year: 2014 Volume: 289 Issue: 26

Year: 2014 Volume: 289 Issue: 25

Year: 2014 Volume: 289 Issue: 24

Year: 2014 Volume: 289 Issue: 23

Year: 2014 Volume: 289 Issue: 22

Year: 2014 Volume: 289 Issue: 21

Year: 2014 Volume: 289 Issue: 20

Year: 2014 Volume: 289 Issue: 19

Year: 2014 Volume: 289 Issue: 18

Year: 2014 Volume: 289 Issue: 17

Year: 2014 Volume: 289 Issue: 16

Year: 2014 Volume: 289 Issue: 15

Year: 2014 Volume: 289 Issue: 14

Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction.

Phosphatidylinositol 4,5-bisphosphate alters the number of attachment sites between ezrin and actin filaments: a colloidal probe study.

Myristoylation restricts orientation of the GRASP domain on membranes and promotes membrane tethering.

FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis.

Ectodomain Movements of an ATP-gated Ion Channel (P2X2 Receptor) Probed by Disulfide $Locking^{*}$

Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.

A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.

(-)-Epicatechin gallate (ECG) stimulates osteoblast differentiation via Runt-related transcription factor 2 (RUNX2) and transcriptional coactivator with PDZ-binding motif (TAZ)-mediated transcriptional activation.

The nuclear calcium signaling target, activating transcription factor 3 (ATF3), protects against dendrotoxicity and facilitates the recovery of synaptic transmission after an excitotoxic insult.

Mice lacking selenoprotein P and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures.

Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.

Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue.

The molecular and metabolic influence of long term agmatine consumption.

Proteolysis of apolipoprotein A-I by secretory phospholipase A2: a new link between inflammation and atherosclerosis.

Capturing a Reactive State of Amyloid Aggregates: NMR-BASED CHARACTERIZATION OF COPPER-BOUND ALZHEIMER DISEASE AMYLOID β-FIBRILS IN A REDOX CYCLE

Identification of ligand specificity determinants in lantibiotic bovicin HJ50 and the receptor BovK, a multitransmembrane histidine kinase.

ADP ribosylation factor 6 (Arf6) acts through FilGAP protein to down-regulate Rac protein and regulates plasma membrane blebbing.

Annexin A2 Mediates Apical Trafficking of Renal $Na^{+}-K^{+}-2Cl^{−}$ Cotransporter

Sensitivity of the polymerase of vesicular stomatitis virus to 2' substitutions in the template and nucleotide triphosphate during initiation and elongation.

Nucleotide-free MalK drives the transition of the maltose transporter to the inward-facing conformation.

An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly.

The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.

ATPase Activity and ATP-dependent Conformational Change in the Co-chaperone HSP70/HSP90-organizing Protein $(HOP)^{*}$

The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells.

Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex.

Hydrogen Sulfide Suppresses Oxidized Low-density Lipoprotein (Ox-LDL)-stimulated Monocyte Chemoattractant Protein 1 generation from Macrophages via the Nuclear Factor κB (NF-κB) Pathway

Conformational transitions of the cross-linking domains of elastin during self-assembly.

Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-ß (TGF-ß) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.

Accumulation of free oligosaccharides and tissue damage in cytosolic -mannosidase (Man2c1)-deficient mice.

Polymorphisms in the Human Inhibitory Signal-regulatory Protein α Do Not Affect Binding to Its Ligand $CD47^{*}$

In the beginning, there was protein phosphorylation.

Loss of syndecan-1 induces a pro-inflammatory phenotype in endothelial cells with a dysregulated response to atheroprotective flow.

Microbial protein-tyrosine kinases.

Structural and Functional Insights into the Human Börjeson-Forssman-Lehmann Syndrome-associated Protein PHF6

Bacterial serine/threonine protein kinases in host-pathogen interactions.

Protein Ser/Thr/Tyr phosphorylation in the Archaea.

Threonine 680 phosphorylation of FLJ00018/PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by epidermal growth factor receptor signaling regulates cell morphology of Neuro-2a cells.

High Oxygen Condition Facilitates the Differentiation of Mouse and Human Pluripotent Stem Cells into Pancreatic Progenitors and Insulin-producing Cells

The ancient microbial RIO kinases.

Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury.

Growth differentiation factor (GDF)-15 blocks norepinephrine-induced myocardial hypertrophy via a novel pathway involving inhibition of epidermal growth factor receptor transactivation.

MicroRNA-29b regulates ethanol-induced neuronal apoptosis in the developing cerebellum through SP1/RAX/PKR cascade.

Introduction of a Synthetic $CO_{2}-fixing$ Photorespiratory Bypass into a Cyanobacterium

A bifunctional glycosyltransferase from Agrobacterium tumefaciens synthesizes monoglucosyl and glucuronosyl diacylglycerol under phosphate deprivation.

Fatty acid chain elongation in palmitate-perfused working rat heart: mitochondrial acetyl-CoA is the source of two-carbon units for chain elongation.

2-Hydroxypropyl-ß-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy.

Lipid raft- and protein kinase C-mediated synergism between glucocorticoid- and gonadotropin-releasing hormone signaling results in decreased cell proliferation.

Trans-activation Response (TAR) RNA-binding Protein 2 Is a Novel Modulator of Transient Receptor Potential Canonical 4 (TRPC4) Protein

Menin is required for optimal processing of the microRNA let-7a.

Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.

Yeast Pah1p phosphatidate phosphatase is regulated by proteasome-mediated degradation.

Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading.

Myocilin regulates cell proliferation and survival.

Fibroblast Growth Factor-based Signaling through Synthetic Heparan Sulfate Blocks Copolymers Studied Using High Cell Density Three-dimensional Cell Printing

Structure-function elucidation of a new -conotoxin, Lo1a, from Conus longurionis.

The assembly and intermolecular properties of the Hsp70-Tomm34-Hsp90 molecular chaperone complex.

Separate Cyclic AMP Sensors for Neuritogenesis, Growth Arrest, and Survival of Neuroendocrine Cells

Identification of Target Binding Site in Photoreceptor Guanylyl Cyclase-activating Protein 1 (GCAP1)

The mitochondrial intermembrane space oxireductase Mia40 funnels the oxidative folding pathway of the cytochrome c oxidase assembly protein Cox19.

N-terminal Isoforms of the Large-conductance $Ca^{2+}-activated$ $K^{+}$ Channel Are Differentially Modulated by the Auxiliary β1-Subunit

The efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer-specific nanoclustering.

A Novel Mechanism by Which Tissue Transglutaminase Activates Signaling Events That Promote Cell Survival

Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells.

Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel.

Developmental regulation of synthesis and dimerization of the amyloidogenic protease inhibitor cystatin C in the hematopoietic system.

Signaling by the extracellular matrix protein Reelin promotes granulosa cell proliferation in the chicken follicle.

Identification of fibroblast growth factor-18 as a molecule to protect adult articular cartilage by gene expression profiling.

Non-Neanderthal origin of the HLA-DPB1*0401.

Reply to Ding et al.: Non-Neanderthal origin of the HLA-DPB1*0401.

Year: 2014 Volume: 289 Issue: 13

Year: 2014 Volume: 289 Issue: 12

Year: 2014 Volume: 289 Issue: 11

Year: 2014 Volume: 289 Issue: 10

Year: 2014 Volume: 289 Issue: 9

Year: 2014 Volume: 289 Issue: 8

Year: 2014 Volume: 289 Issue: 7

Year: 2014 Volume: 289 Issue: 6

Year: 2014 Volume: 289 Issue: 5

Year: 2014 Volume: 289 Issue: 4

Year: 2014 Volume: 289 Issue: 3

Year: 2014 Volume: 289 Issue: 2

Year: 2014 Volume: 289 Issue: 1

Year: 2013 Volume: 288

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2008 Volume: 283

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

Hydrogen Sulfide Suppresses Oxidized Low-density Lipoprotein (Ox-LDL)-stimulated Monocyte Chemoattractant Protein 1 generation from Macrophages via the Nuclear Factor κB (NF-κB) Pathway

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Qiaoli Jin, Hongfang Huang, Yaqian Zhu, Mingzhu Chen, Stella X. Yan, Hui Zhao, Manman Bu, Dingfang Du, Junbao Liu, Jia Tang, Chaoshu
Description	Author Affiliation: Du J ( From the Department of Pediatrics and.)
Abstract	This study was designed to examine the role of hydrogen sulfide (H2S) in the generation of oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 (MCP-1) from macrophages and possible mechanisms. THP-1 cells and RAW macrophages were pretreated with sodium hydrosulfide (NaHS) and hexyl acrylate and then treated with ox-LDL. The results showed that ox-LDL treatment down-regulated the H2S/cystathionine-ß-synthase pathway, with increased MCP-1 protein and mRNA expression in both THP-1 cells and RAW macrophages. Hexyl acrylate promoted ox-LDL-induced inflammation, whereas the H2S donor NaHS inhibited it. NaHS markedly suppressed NF-κB p65 phosphorylation, nuclear translocation, DNA binding activity, and recruitment to the MCP-1 promoter in ox-LDL-treated macrophages. Furthermore, NaHS decreased the ratio of free thiol groups in p65, whereas the thiol reductant DTT reversed the inhibiting effect of H2S on the p65 DNA binding activity. Most importantly, site-specific mutation of cysteine 38 to serine in p65 abolished the effect of H2S on the sulfhydration of NF-κB and ox-LDL-induced NF-κB activation. These results suggested that endogenous H2S inhibited ox-LDL-induced macrophage inflammation by suppressing NF-κB p65 phosphorylation, nuclear translocation, DNA binding activity, and recruitment to the MCP-1 promoter. The sulfhydration of free thiol group on cysteine 38 in p65 served as a molecular mechanism by which H2S inhibited NF-κB pathway activation in ox-LDL-induced macrophage inflammation.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	14
Volume Number	289
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2014-04-04
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chemokine CCL2 Biosynthesis Gasotransmitters Pharmacology Gene Expression Regulation Drug Effects Hydrogen Sulfide Lipoproteins, LDL Toxicity Macrophages Metabolism Transcription Factor RelA Active Transport, Cell Nucleus Genetics Animals Cell Line Cell Nucleus Pathology Inflammation Chemically Induced Mice Phosphorylation RNA, Messenger Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in