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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hong, Jeong-ho Noh, Minsoo Sung, Mi Kyung Lee, Cham Han Jang, Eun Jung Jeong, Mi Gyeong Byun, Mi Ran Hwang, Eun Sook Kim, A. Rum |
| Description | Author Affiliation: Byun MR ( From the Division of Life Sciences, Korea University, Seoul 136-701, Korea.) |
| Abstract | Osteoporosis is a degenerative bone disease characterized by low bone mass and is caused by an imbalance between osteoblastic bone formation and osteoclastic bone resorption. It is known that the bioactive compounds present in green tea increase osteogenic activity and decrease the risk of fracture by improving bone mineral density. However, the detailed mechanism underlying these beneficial effects has yet to be elucidated. In this study, we investigated the osteogenic effect of (-)-epicatechin gallate (ECG), a major bioactive compound found in green tea. We found that ECG effectively stimulates osteoblast differentiation, indicated by the increased expression of osteoblastic marker genes. Up-regulation of osteoblast marker genes is mediated by increased expression and interaction of the transcriptional coactivator with PDZ-binding motif (TAZ) and Runt-related transcription factor 2 (RUNX2). ECG facilitates nuclear localization of TAZ through PP1A. PP1A is essential for osteoblast differentiation because inhibition of PP1A activity was shown to suppress ECG-mediated osteogenic differentiation. Taken together, the results showed that ECG stimulates osteoblast differentiation through the activation of TAZ and RUNX2, revealing a novel mechanism for green tea-stimulated osteoblast differentiation. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 14 |
| Volume Number | 289 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2014-04-04 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antineoplastic Agents, Phytogenic Pharmacology Catechin Analogs & Derivatives Cell Differentiation Drug Effects Cell Nucleus Metabolism Core Binding Factor Alpha 1 Subunit Osteoblasts Transcription Factors Biosynthesis Transcriptional Activation Active Transport, Cell Nucleus Physiology Animals Cell Line Genetics Mice Cytology Protein Phosphatase 2 Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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