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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Da Graca, Abel Pereira Paululat, Achim Sündermann, Frederik Meyer, Heiko Appel, Neele Bakota, Lidia Brandt, Roland Moschner, Katharina |
| Description | Author Affiliation: Moschner K ( From the Departments of Neurobiology and.); Sündermann F ( From the Departments of Neurobiology and.); Meyer H ( Zoology, University of Osnabrück, 49076 Osnabrück, Germany.); da Graca AP ( From the Departments of Neurobiology and.); Appel N ( From the Departments of Neurobiology and.); Paululat A ( Zoology, University of Osnabrück, 49076 Osnabrück, Germany.); Bakota L ( From the Departments of Neurobiology and.); Brandt R ( From the Departments of Neurobiology and brandt@biologie.uni-osnabrueck.de.) |
| Abstract | The neuronal microtubule-associated protein Tau is expressed in different variants, and changes in Tau isoform composition occur during development and disease. Here, we investigate a potential role of the multivalent tau mRNA-binding proteins G3BP1 and IMP1 in regulating neuronal tau expression. We demonstrate that G3BP1 and IMP1 expression induces the formation of structures, which qualify as neuronal ribonucleoprotein (RNP) granules and concentrate multivalent proteins and mRNA. We show that RNP granule formation leads to a >30-fold increase in the ratio of high molecular weight to low molecular weight tau mRNA and an â ¼12-fold increase in high molecular weight to low molecular weight Tau protein. We report that RNP granule formation is associated with increased neurite formation and enhanced process growth. G3BP1 deletion constructs that do not induce granule formation are also deficient in inducing neuronal sprouting or changing the expression pattern of tau. The data indicate that granule formation driven by multivalent proteins modulates tau isoform expression and suggest a morphoregulatory function of RNP granules during health and disease. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 24 |
| Volume Number | 289 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2014-06-13 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cytoplasmic Granules Metabolism Neurons RNA, Messenger Ribonucleoproteins Tau Proteins Animals Carrier Proteins Genetics Cell Growth Processes Gene Deletion Physiology PC12 Cells Protein Isoforms RNA-Binding Proteins Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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