Embryonic lethal abnormal vision-like rna-binding proteins regulate neurite outgrowth and tau expression in pc12 cells.

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Author	Ar, Gonzalo E. Behar, Leah Chung, Sangmi Furneaux, Henry Ginzburg, Irith
Abstract	The embryonic lethal abnormal vision (ELAV)-like proteins are mRNA-binding proteins that regulate mRNA stability. The neuronal members of this family are required for neuronal differentiation. We identified the binding region of purified HuD protein to a target neuronal mRNA encoding for the tau microtubuleassociated protein and demonstrated an in vivo interaction between the ELAV-like protein and its target tau mRNA. We show that treatment of neuronal cells with antisense oligodeoxynucleotides directed against HuD blocks the induction of neurite outgrowth and decreases the levels of tau mRNAs, indicating that the ELAV-like proteins are required for neuronal differentiation. Key words: RNA-binding proteins; tau mRNA; mRNA stabilization; neurite outgrowth; antisense oligodeoxynucleotides; microtubules
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Subject Keyword	Tau Expression Pc12 Cell Neuronal Differentiation Elav-like Protein Antisense Oligodeoxynucleotides Neurite Outgrowth Tau Mrna Target Tau Mrna Binding Region Embryonic Lethal Abnormal Vision Rna-binding Protein Neuronal Member Mrna Stability Target Neuronal Mrna Purified Hud Protein Mrna-binding Protein Vivo Interaction Neuronal Cell
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