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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Buelto, Destiney Wendland, Beverly Martinez-marquez, Jorge Y. Prosser, Derek C. Ganser, Laura R. Duncan, Mara C. Lang, Michael J. |
| Description | Author Affiliation: Lang MJ ( From the Department of Cell and Developmental Biology, the University of Michigan, Ann Arbor, Michigan 48109.); Martinez-Marquez JY ( From the Department of Cell and Developmental Biology, the University of Michigan, Ann Arbor, Michigan 48109.); Prosser DC ( the Department of Biology, the Johns Hopkins University, Baltimore, Maryland 21218, and.); Ganser LR ( the Department of Biology, the University of North Carolina, Chapel Hill, North Carolina 27599.); Buelto D ( the Curriculum in Genetics and Molecular Biology, the University of North Carolina, Chapel Hill, North Carolina 27599.); Wendland B ( the Department of Biology, the Johns Hopkins University, Baltimore, Maryland 21218, and.); Duncan MC ( From the Department of Cell and Developmental Biology, the University of Michigan, Ann Arbor, Michigan 48109, the Department of Biology, the University of North Carolina, Chapel Hill, North Carolina 27599, the Curriculum in Genetics and Molecular Biology, the University of North Carolina, Chapel Hil) |
| Abstract | Cellular energy influences all aspects of cellular function. Although cells can adapt to a gradual reduction in energy, acute energy depletion poses a unique challenge. Because acute depletion hampers the transport of new energy sources into the cell, the cell must use endogenous substrates to replenish energy after acute depletion. In the yeast Saccharomyces cerevisiae, glucose starvation causes an acute depletion of intracellular energy that recovers during continued glucose starvation. However, how the cell replenishes energy during the early phase of glucose starvation is unknown. In this study, we investigated the role of pathways that deliver proteins and lipids to the vacuole during glucose starvation. We report that in response to glucose starvation, plasma membrane proteins are directed to the vacuole through reduced recycling at the endosomes. Furthermore, we found that vacuolar hydrolysis inhibits macroautophagy in a target of rapamycin complex 1-dependent manner. Accordingly, we found that endocytosis and hydrolysis are required for survival in glucose starvation, whereas macroautophagy is dispensable. Together, these results suggest that hydrolysis of components delivered to the vacuole independent of autophagy is the cell survival mechanism used by S. cerevisiae in response to glucose starvation. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 24 |
| Volume Number | 289 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2014-06-13 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Autophagy Cell Membrane Metabolism Endocytosis Glucose Deficiency Saccharomyces Cerevisiae Vacuoles Down-Regulation Hydrolysis Lipid Metabolism Multiprotein Complexes Protein Transport Saccharomyces Cerevisiae Proteins TOR Serine-Threonine Kinases Research Support, N.I.H., Extramural Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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