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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yoder, Bradley K. Frederick, Jeanne M. Baehr, Wolfgang Jiang, Li Marc, Robert E. Ronquillo, Cecinio C. Wei, Yuxiao |
| Description | Author Affiliation: Jiang L ( From the Departments of Ophthalmology and Visual Sciences and li.jiang@hsc.utah.edu.); Wei Y ( From the Departments of Ophthalmology and Visual Sciences and.); Ronquillo CC ( From the Departments of Ophthalmology and Visual Sciences and.); Marc RE ( From the Departments of Ophthalmology and Visual Sciences and.); Yoder BK ( the Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, and.); Frederick JM ( From the Departments of Ophthalmology and Visual Sciences and.); Baehr W ( From the Departments of Ophthalmology and Visual Sciences and the Department of Biology, University of Utah, Salt Lake City, Utah 84112 Neurobiology and Anatomy, University of Utah Health Science Center, Salt Lake City, Utah 84132, wbaehr@hsc.utah.edu.) |
| Abstract | Anterograde intraflagellar transport (IFT) employing kinesin-2 molecular motors has been implicated in trafficking of photoreceptor outer segment proteins. We generated embryonic retina-specific (prefix 'emb') and adult tamoxifen-induced (prefix 'tam') deletions of KIF3a and IFT88 in adult mice to study photoreceptor ciliogenesis and protein trafficking. In (emb)Kif3a(-/-) and in (emb)Ift88(-/-) mice, basal bodies failed to extend transition zones (connecting cilia) with outer segments, and visual pigments mistrafficked. In contrast, (tam)Kif3a(-/-) and (tam)Ift88(-/-) photoreceptor axonemes disintegrated slowly post-induction, starting distally, but rhodopsin and cone pigments trafficked normally for more than 2 weeks, a time interval during which the outer segment is completely renewed. The results demonstrate that visual pigments transport to the retinal outer segment despite removal of KIF3 and IFT88, and KIF3-mediated anterograde IFT is responsible for photoreceptor transition zone and axoneme formation. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 20 |
| Volume Number | 290 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2015-05-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Axoneme Metabolism Kinesin Retinal Cone Photoreceptor Cells Rhodopsin Animals Genetics Basal Bodies Mice Mice, Knockout Protein Transport Physiology Cytology Tumor Suppressor Proteins Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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