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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Maeda, Akiko Maeda, Tadao Golczak, Marcin Palczewski, Krzysztof |
| Description | Author Affiliation: Maeda A ( Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA.) |
| Abstract | The visual (retinoid) cycle is a fundamental metabolic process in vertebrate retina responsible for production of 11-cis-retinal, the chromophore of rhodopsin and cone pigments. 11-cis-Retinal is bound to opsins, forming visual pigments, and when the resulting visual chromophore 11-cis-retinylidene is photoisomerized to all-trans-retinylidene, all-trans-retinal is released from these receptors. Toxic byproducts of the visual cycle formed from all-trans-retinal often are associated with lipofuscin deposits in the retinal pigmented epithelium (RPE), but it is not clear whether aberrant reactions of the visual cycle participate in RPE atrophy, leading to a rapid onset of retinopathy. Here we report that mice lacking both the ATP-binding cassette transporter 4 (Abca4) and enzyme retinol dehydrogenase 8 (Rdh8), proteins critical for all-trans-retinal clearance from photoreceptors, developed severe RPE/photoreceptor dystrophy at an early age. This phenotype includes lipofuscin, drusen, and basal laminar deposits, Bruch's membrane thickening, and choroidal neovascularization. Importantly, the severity of visual dysfunction and retinopathy was exacerbated by light but attenuated by treatment with retinylamine, a visual cycle inhibitor that slows the flow of all-trans-retinal through the visual cycle. These findings provide direct evidence that aberrant production of toxic condensation byproducts of the visual cycle in mice can lead to rapid, progressive retinal degeneration. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 39 |
| Volume Number | 283 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2008-09-26 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Pigment Epithelium Of Eye Metabolism Retinal Cone Photoreceptor Cells Retinaldehyde Retinitis Pigmentosa Rhodopsin ATP-Binding Cassette Transporters Genetics Alcohol Oxidoreductases Animals Bruch Membrane Pathology Lipofuscin Mice Mice, Knockout Retinal Drusen Vision, Ocular Research Support, N.I.H., Extramural Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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