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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Yin Cao, Youjia Liu, Yaohui Zhang, Liming He, Bin Wang, Yu Pan, Shuang Wu, Songfang Zhang, Cuizhu Chen, Da Lan, Bei Leng, Qianli |
| Description | Author Affiliation: Yang Y ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and.); Wu S ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and.); Wang Y ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and.); Pan S ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and.); Lan B ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and.); Liu Y ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and.); Zhang L ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and.); Leng Q ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and.); Chen D ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and.); Zhang C ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and czz912@aliyun.com.); He B ( the Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612 tshuo@uic.edu.); Cao Y ( From the Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and caoyj@nankai.edu.cn.) |
| Abstract | Herpes simplex virus 1 (HSV-1) is the most prevalent human virus and causes global morbidity because the virus is able to infect multiple cell types. Remarkably, HSV infection switches between lytic and latent cycles, where T cells play a critical role. However, the precise way of virus-host interactions is incompletely understood. Here we report that HSV-1 productively infected Jurkat T-cells and inhibited antigen-induced T cell receptor activation. We discovered that HSV-1-encoded Us3 protein interrupted TCR signaling and interleukin-2 production by inactivation of the linker for activation of T cells. This study unveils a mechanism by which HSV-1 intrudes into early events of TCR-mediated cell signaling and may provide novel insights into HSV infection, during which the virus escapes from host immune surveillance. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 25 |
| Volume Number | 290 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2015-06-19 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adaptor Proteins, Signal Transducing Immunology Herpes Simplex Herpesvirus 1, Human Membrane Proteins Protein-Serine-Threonine Kinases Signal Transduction T-Lymphocytes TNF Receptor-Associated Factor 6 Viral Proteins Genetics Pathology Immune Evasion Interleukin-2 Jurkat Cells Receptors, Antigen, T-Cell Virology Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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