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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kaddai, Vincent A. Chaurasia, Bhagirath Li, Ying Summers, Scott A. Siddique, Monowarul Mobin |
| Description | Author Affiliation: Siddique MM ( From the Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.); Li Y ( From the Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.); Chaurasia B ( From the Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.); Kaddai VA ( From the Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.); Summers SA ( From the Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia Scott.summers@bakeridi.edu.au.) |
| Abstract | Sphingolipid synthesis involves a highly conserved biosynthetic pathway that produces fundamental precursors of complex sphingolipids. The final reaction involves the insertion of a double bond into dihydroceramides to generate the more abundant ceramides, which are converted to sphingomyelins and glucosylceramides/gangliosides by the addition of polar head groups. Although ceramides have long been known to mediate cellular stress responses, the dihydroceramides that are transiently produced during de novo sphingolipid synthesis were deemed inert. Evidence published in the last few years suggests that these dihydroceramides accumulate to a far greater extent in tissues than previously thought. Moreover, they have biological functions that are distinct and non-overlapping with those of the more prevalent ceramides. Roles are being uncovered in autophagy, hypoxia, and cellular proliferation, and the lipids are now implicated in the etiology, treatment, and/or diagnosis of diabetes, cancer, ischemia/reperfusion injury, and neurodegenerative diseases. This minireview summarizes recent findings on this emerging class of bioactive lipids. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 25 |
| Volume Number | 290 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2015-06-19 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Ceramides Metabolism Diabetes Mellitus Neoplasms Neurodegenerative Diseases Reperfusion Injury Animals Autophagy Cell Proliferation Genetics Diagnosis Pathology Sphingomyelins Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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