NDLI: The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation

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The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bartelt, Rebekah R. Houtman, Jon C. D.
Description	Country affiliation: United States Author Affiliation: Bartelt RR ( Department of Microbiology, University of Iowa, Iowa City, IA, USA.)
Abstract	T cells are essential for the adaptive immune response to pathogens. However, dysfunctional T cell activity has been implicated in numerous diseases, including the failure of organ transplants, allergic reactions, asthma, autoimmune disorders, and coronary artery disease. T cell responses to pathogens require the induction of the primary activating receptor, the T cell receptor (TCR), along with other costimulatory and adhesion receptors. Signal transduction pathways activated downstream of these receptors drive T cell responses required for the immune response and disease progression. A key question in our understanding of the mechanism of T cell activation is how signalling pathways emanating from multiple receptors integrate together to alter T cell effector functions. One integration node for intracellular signalling is the membrane-associated adaptor protein linker for the activation of T cells or LAT. Upon stimulation of the TCR and other receptors, LAT is phosphorylated at several tyrosines residues on its cytoplasmic tail. This leads to the binding of SH2-domain containing proteins and their associated molecules and the formation of large multiprotein complexes. These dynamic and highly regulated signalling complexes facilitate the production of second messengers, activate downstream pathways, induce actin cytoskeleton polymerization, and stimulate the activity of multiple transcription factors. Thus, signalling pathways from several receptors feed into LAT, which then integrates this information and selectively induces pathways critical for T cell activation and the adaptive immune response.
File Format	HTM / HTML
ISSN	19395094
e-ISSN	1939005X
DOI	10.1002/wsbm.1194
Journal	Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Issue Number	1
Volume Number	5
Language	English
Publisher	Wiley
Publisher Date	2013-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Computational Biology Adaptive Immunity Immunology Adaptor Proteins, Signal Transducing Lymphocyte Activation Signal Transduction Animals Mice
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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