NDLI: Major impact of N-methylation on cytotoxicity and hydrolysis of salan Ti(IV) complexes: sterics and electronics are intertwined

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Meker, Sigalit Tshuva, Edit Y. Manna, Cesar M. Peri, Dani
Description	Author Affiliation: Meker S ( Institute of Chemistry, The Hebrew University of Jerusalem, Israel. tshuva@chem.ch.huji.ac.il)
Abstract	A series of Ti(IV) complexes containing diamino bis(phenolato) “salan” type ligands with NH coordination were prepared, and their hydrolysis and cytotoxicity were analyzed and compared to the N-methylated analogues. Substituting methyl groups on the coordinative nitrogen donor of highly active and stable Ti(IV) salan complexes with H atoms has two main consequences: the hydrolysis rate increases and the cytotoxic activity diminishes. In addition, the small modification of a single replacement of Me with H leads to a different major hydrolysis product, where a dinuclear Ti(IV) complex with two bridging oxo ligands is obtained, as characterized by X-ray crystallography , rather than a trinuclear cluster. A partial hydrolysis product containing a single oxo bridge was also crystallographically analyzed. Investigation of a series of complexes with NH donors of different steric and electronic effects revealed that cytotoxicity may be restored by fine tuning these parameters even for complexes of low stability.
ISSN	14779226
Issue Number	38
Volume Number	40
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2011-10-14
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Antineoplastic Agents Pharmacology Coordination Complexes Phenols Chemistry Titanium Chemical Synthesis Cell Line, Tumor Cell Proliferation Drug Effects Cell Survival Crystallography, X-Ray Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Electronics HT29 Cells Humans Hydrolysis Methylation Models, Molecular Molecular Structure Stereoisomerism Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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