NDLI: pH luminescence switch, DNA binding and photocleavage, and cytotoxicity of a dinuclear ruthenium complex

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhao, Xiao-long Li, Zhen-sheng Zheng, Ze-bao Zhang, An-guo Wang, Ke-zhi
Description	Author Affiliation: Zhao XL ( College of Chemistry, Beijing Key Laboratory of Energy Conversion and Storage Materials, Beijing Normal University, Beijing 100875, PR China.)
Abstract	The ground- and excited-state acid–base properties of $[Ru_{2}(bpy)_{4}(H_{2}bipt)]Cl_{4}1$ {bpy = 2,2′-bipyridine, $H_{2}bipt$ = 2,5-bis[1,10]phenanthrolin[4,5-f]-imidazol-2-yl)thiophene} are investigated by emission and UV-visible absorption spectrophotometric pH titrations. The DNA binding properties of 1 are studied by means of DNA viscosity and optical spectroscopic techniques of UV-visible absorption and emission spectral titrations, steady-state emission quenching with ferrocyanide, ethidium bromide competitive binding, and DNA thermal denaturation as well as density functional theoretical calculations. The DNA photocleavage and singlet oxygen generation properties as well as in vitro anticancer activities against five cancer cell lines are studied as well. The results demonstrated that pH-induced luminescence switching, DNA binding, and anticancer properties of 1 are much improved with respect to those of the mononuclear analog $[Ru(bpy)_{2}(Htip)]Cl_{2}$ {Htip = 2-(thiophen-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline}.
ISSN	14779226
Issue Number	16
Volume Number	42
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2013-04-28
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Antineoplastic Agents Chemistry Coordination Complexes DNA Metabolism Ruthenium Toxicity Apoptosis Drug Effects Cell Line, Tumor HeLa Cells Hep G2 Cells Humans Hydrogen-Ion Concentration MCF-7 Cells Nucleic Acid Denaturation Photolysis Quantum Theory Singlet Oxygen Spectrophotometry, Ultraviolet Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in