NDLI: Synthesis, solid-state characterization and solution studies of new phytate compounds with Cu(II) and 1,10-phenanthroline: progress in the structural elucidation of phytate coordinating ability

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bazzicalupi, C. Bianchi, A. Castiglioni, J. Kremer, C. Torres, J. Veiga, N. Quiñone, D.
Description	Author Affiliation: Quiñone D ( Departamento Estrella Campos, Facultad de Química, Universidad de la República, Montevideo, Uruguay. ckremer@fq.edu.uy.); Veiga N ( Departamento Estrella Campos, Facultad de Química, Universidad de la República, Montevideo, Uruguay. ckremer@fq.edu.uy.); Torres J ( Departamento Estrella Campos, Facultad de Química, Universidad de la República, Montevideo, Uruguay. ckremer@fq.edu.uy.); Castiglioni J ( LAFIDESU, DETEMA, Facultad de Química, Universidad de la República, Montevideo, Uruguay.); Bazzicalupi C ( Dipartimento di Chimica 'Ugo Schiff', Universitá degli Studi di Firenze, Firenze, Italy. antonio.bianchi@unifi.it.); Bianchi A ( Dipartimento di Chimica 'Ugo Schiff', Universitá degli Studi di Firenze, Firenze, Italy. antonio.bianchi@unifi.it.); Kremer C ( Departamento Estrella Campos, Facultad de Química, Universidad de la República, Montevideo, Uruguay. ckremer@fq.edu.uy.)
Abstract	Within all the eukaryotic cells there is an important group of biomolecules that has been potentially related to signalling functions: myo-inositol phosphates $(InsP_{s}).$ In nature, the most abundant member of this family is the so called phytate $(InsP_{6},$ $L^{12−}).$ The importance of the interaction of $InsP_{6}$ with cations has been recognized during the last few years, and any attempt to know the function of this molecule in eukaryotic cells must include the fact that $InsP_{6}$ will be strongly associated with simple inorganic or organic ammonium cations. In this work we expand on our earlier findings by studying the systems phen–phytate (phen = 1,10-phenanthroline) and Cu(II)–phen–phytate. The structures of $(Hphen)_{4}(H_{8}L)·7.5H_{2}O$ and $[Cu_{5}(H_{7}L)_{2}(H_{2}O)_{2}(phen)_{5}]·23H_{2}O$ are presented. Solution studies of the binary and ternary systems were also performed by means of potentiometric titrations at 37.0 °C and 0.15 M ionic strength. The work was completed with a molecular modelling study. All this information is essential in the process of gaining reliable structural knowledge about the most important $InsP_{6}$ species in the in vitro and in vivo experiments, and how these features modulate their probable biological functions.
ISSN	14779226
Issue Number	30
Journal	Dalton Trans.
Volume Number	45
e-ISSN	13645447
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-07-26
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Chemistry
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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