NDLI: Light-triggered CO delivery by a water-soluble and biocompatible manganese photoCORM

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jimenez, Jorge Mascharak, Pradip K. Carrington, Samantha J. Chakraborty, Indranil
Description	Author Affiliation: Jimenez J ( Contribution form the Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. Pradip@ucsc.edu.); Chakraborty I ( Contribution form the Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. Pradip@ucsc.edu.); Carrington SJ ( Contribution form the Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. Pradip@ucsc.edu.); Mascharak PK ( Contribution form the Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. Pradip@ucsc.edu.)
Abstract	The discovery of salutary effects of low doses of carbon monoxide (CO) has spurred interest in designing exogenous molecules that can deliver CO to biological targets under controlled conditions. Herein we report a water-soluble photosensitive manganese carbonyl complex $[MnBr(CO)_{3}(pyTAm)]$ (2) (pyTAm = 2-(pyridyl)imino-triazaadamantane) that can be triggered to release CO upon exposure to visible light. Inclusion of a triazaadamantyl pharmacophore into the coligand of 2 improves its stability and solubility in water. Change in the coligand from 2-(pyridyl)imino-triazaadamantane to 2-(pyridyl)iminoadamantane (pyAm) or 2-(quinonyl)imino-triazaadamantane (qyTAm) dramatically alters these desired properties of the photoCORM. In addition to structures and CO-releasing properties of the three analogous complexes 1–3 from these three α-diimine ligands, theoretical calculations have been performed to determine the origin of Mn–CO bond labilization upon illumination. Rapid delivery of CO to myoglobin under physiological conditions attests the potential of 2 as a biocompatible photoCORM.
ISSN	14779226
Issue Number	33
Journal	Dalton Trans.
Volume Number	45
e-ISSN	13645447
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-08-16
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Chemistry
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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