NDLI: Antiproliferative activity of ruthenium(II) arene complexes with mono- and bidentate pyridine-based ligands

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Richter, Stefan Kumbhar, Anupa Maksimovic-ivanic, Danijela Singh, Sushma Kate, Anup Kumbhar, Avinash S. Draca, Dijana Hey-hawkins, Evamarie Lönnecke, Peter Mijatovic, Sanja
Description	Author Affiliation: Richter S ( Universität Leipzig, Institut für Anorganische Chemie, Johannisallee 29, 04103 Leipzig, Germany. hey@uni-leipzig.de.); Singh S ( Department of Chemistry, Savitribai Phule Pune University, Pune-411007, India.); Draca D ( Institute for Biological Research 'Sinisa Stankovic', University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.); Kate A ( Department of Chemistry, Savitribai Phule Pune University, Pune-411007, India.); Kumbhar A ( Department of Chemistry, Savitribai Phule Pune University, Pune-411007, India.); Kumbhar AS ( Department of Chemistry, Savitribai Phule Pune University, Pune-411007, India.); Maksimovic-Ivanic D ( Institute for Biological Research 'Sinisa Stankovic', University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.); Mijatovic S ( Institute for Biological Research 'Sinisa Stankovic', University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.); Lönnecke P ( Universität Leipzig, Institut für Anorganische Chemie, Johannisallee 29, 04103 Leipzig, Germany. hey@uni-leipzig.de.); Hey-Hawkins E ( Universität Leipzig, Institut für Anorganische Chemie, Johannisallee 29, 04103 Leipzig, Germany. hey@uni-leipzig.de.)
Abstract	A series of $Ru^{II}$ arene complexes of mono- and bidentate N-donor ligands with carboxyl or ester groups and chlorido ancillary ligands were synthesised and structurally characterised. The complexes have a distorted tetrahedral piano-stool geometry. The binding interaction was studied with calf thymus DNA (CT-DNA) by absorption titration, viscosity measurement, thermal melting, circular dichroism, ethidium bromide displacement assay and DNA cleavage of plasmid DNA (pBR322), investigated by gel electrophoresis. The dichlorido complexes bind covalently to DNA in the dark, similar to cisplatin, while the monochlorido complexes bind covalently on irradiation, similar to cisplatin analogues. The compounds are selectively cytotoxic against several tumour cell lines and show specific nonlinear correlation between dose and activity. This phenomenon is closely related to their potential to act preferentially as inhibitors of cell division.
ISSN	14779226
Issue Number	33
Journal	Dalton Trans.
Volume Number	45
e-ISSN	13645447
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-08-16
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Chemistry
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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